Pdia6 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pdia6
protein disulfide isomerase associated 6
MGI:1919103

38 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pdia6^em1Btlr/Pdia6^em1Btlr Not Specified	preweaning lethality, complete penetrance	J:288824
Pdia6^em1Btlr/Pdia6^m1Btlr involves: C57BL/6J	abnormal circulating cytokine level	J:288824
	abnormal T cell physiology	J:288824
	decreased B cell number	J:288824
	decreased body size	J:288824
	decreased body weight	J:288824
	decreased circulating insulin level	J:288824
	decreased circulating insulin-like growth factor I level	J:288824
	decreased circulating triglyceride level	J:288824
	decreased common lymphocyte progenitor cell number	J:288824
	decreased common myeloid progenitor cell number	J:288824
	decreased double-negative T cell number	J:288824
	decreased double-positive T cell number	J:288824
	decreased follicular B cell number	J:288824
	decreased hematopoietic stem cell number	J:288824
	decreased leukocyte cell number	J:288824
	decreased lymphocyte cell number	J:288824
	decreased monocyte cell number	J:288824
	decreased NK T cell number	J:288824
	decreased pre-B cell number	J:288824
	decreased transitional stage B cell number	J:288824
	normal endocrine/exocrine gland phenotype	J:288824
	normal hematopoietic system phenotype	J:288824
	increased fasting circulating glucose level	J:288824
	increased granulocyte monocyte progenitor cell number	J:288824
	increased marginal zone B cell number	J:288824
	increased marginal zone precursor B cell number	J:288824
	increased mature B cell number	J:288824
	insulin resistance	J:288824
	spleen hypoplasia	J:288824
	thrombocytopenia	J:288824
	thymus hypoplasia	J:288824
Pdia6^m1Btlr/Pdia6^m1Btlr C57BL/6J-Pdia6^m1Btlr	decreased body weight	J:288824
Pdia6^m1Btlr/Pdia6^m1Btlr C57BL/6J-Pdia6^m1Btlr	normal immune system phenotype	J:288824
Pdia6^{tm1b(EUCOMM)Hmgu}/Pdia6⁺ C57BL/6N-Pdia6^{tm1b(EUCOMM)Hmgu}/Ieg	abnormal gait	J:211773
	decreased CD4-positive NK T cell number	J:211773
	enlarged lymph nodes	J:211773
	enlarged thyroid gland	J:211773
	increased total body fat amount	J:211773
Pdia6^{tm1b(EUCOMM)Hmgu}/Pdia6^{tm1b(EUCOMM)Hmgu} C57BL/6N-Pdia6^{tm1b(EUCOMM)Hmgu}/Ieg	preweaning lethality, complete penetrance	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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