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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tmprss6
transmembrane serine protease 6
MGI:1919003
29 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Hbb-b1tm1Unc/Hbb-b1+
Hbb-b2tm1Unc/Hbb-b2+
Tmprss6tm1Otin/Tmprss6+
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N 		abnormal circulating erythropoietin level J:185154
abnormal erythrocyte cell number J:185154
abnormal erythrocyte morphology J:185154
abnormal hemoglobin content J:185154
abnormal liver iron level J:185154
abnormal spleen iron level J:185154
abnormal spleen size J:185154
decreased mean corpuscular volume J:185154
Hbb-b1tm1Unc/Hbb-b1+
Hbb-b2tm1Unc/Hbb-b2+
Tmprss6tm1Otin/Tmprss6tm1Otin
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N 		abnormal erythrocyte cell number J:185154
abnormal erythrocyte morphology J:185154
abnormal erythroid progenitor cell morphology J:185154
abnormal erythropoiesis J:185154
abnormal hemoglobin content J:185154
abnormal spleen size J:185154
normal homeostasis/metabolism phenotype J:185154
increased circulating erythropoietin level J:185154
reticulocytopenia J:185154
Hjvtm1Nca/Hjv+
Tmprss6tm1Dgen/Tmprss6tm1Dgen
involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6 		abnormal iron level J:160248
decreased erythrocyte cell number J:160248
decreased heart iron level J:160248
decreased hematocrit J:160248
decreased hemoglobin content J:160248
decreased liver iron level J:160248
decreased mean corpuscular hemoglobin concentration J:160248
decreased mean corpuscular volume J:160248
decreased pancreas iron level J:160248
increased red blood cell distribution width J:160248
microcytic anemia J:160248
sparse hair J:160248
Hjvtm1Nca/Hjvtm1Nca
Tmprss6tm1Dgen/Tmprss6+
involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6 		abnormal hepatocyte morphology J:160248
abnormal iron level J:160248
abnormal macrophage morphology J:160248
decreased spleen iron level J:160248
increased liver iron level J:160248
Hjvtm1Nca/Hjvtm1Nca
Tmprss6tm1Dgen/Tmprss6tm1Dgen
involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6 		abnormal hepatocyte morphology J:160248
abnormal iron level J:160248
abnormal macrophage morphology J:160248
decreased spleen iron level J:160248
increased liver iron level J:160248
normal integument phenotype J:160248
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory