Ubr4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ubr4
ubiquitin protein ligase E3 component n-recognin 4
MGI:1916366

32 phenotypes from 5 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ubr4^{Tg(Tyr)2393A-1Ove}/Ubr4^{Tg(Tyr)2393A-1Ove} FVB/N-Ubr4^{Tg(Tyr)2393A-1Ove}	decreased birth body size	J:175597
	neonatal lethality, complete penetrance	J:175597
Ubr4^tm1.1Nkt/Ubr4^tm1.1Nkt involves: 129S6/SvEvTac * C57BL/6 * FVB/N	abnormal placental labyrinth vasculature morphology	J:203460
	decreased embryo size	J:203460
	embryonic lethality during organogenesis, complete penetrance	J:203460
	thin placenta labyrinth	J:203460
Ubr4^tm1.1Ytkw/Ubr4^tm1.1Ytkw involves: 129P2/OlaHsd	abnormal autophagy	J:196073
	abnormal vitelline vascular remodeling	J:196073
	abnormal vitelline vasculature morphology	J:196073
	embryonic growth arrest	J:196073
	embryonic lethality during organogenesis, complete penetrance	J:196073
	pale yolk sac	J:196073
Ubr4^tm1.2Nkt/Ubr4^tm1.2Nkt Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL	abnormal atrioventricular cushion morphology	J:203460
	abnormal brain morphology	J:203460
	abnormal cell death	J:203460
	abnormal fourth ventricle morphology	J:203460
	abnormal head morphology	J:203460
	abnormal heart development	J:203460
	abnormal interventricular septum morphology	J:203460
	abnormal lateral ganglionic eminence morphology	J:203460
	abnormal liver parenchyma morphology	J:203460
	abnormal liver vasculature morphology	J:203460
	abnormal medial ganglionic eminence morphology	J:203460
	decreased brain size	J:203460
	dilated liver sinusoidal space	J:203460
	normal embryo phenotype	J:203460
	embryonic growth retardation	J:203460
	increased cell proliferation	J:203460
	lethality throughout fetal growth and development, complete penetrance	J:203460
	liver hypoplasia	J:203460
	thin ventricular wall	J:203460
Ubr4^{tm1b(EUCOMM)Hmgu}/Ubr4^{tm1b(EUCOMM)Hmgu} C57BL/6N-Ubr4^{tm1b(EUCOMM)Hmgu}/Bay	embryonic lethality prior to tooth bud stage	J:211773
	preweaning lethality, complete penetrance	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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