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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Nadk2
NAD kinase 2, mitochondrial
MGI:1915896
28 phenotypes from 3 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Nadk2em1(IMPC)J/Nadk2+
C57BL/6NJ-Nadk2em1(IMPC)J/J
abnormal embryo size J:211773
decreased fasting circulating glucose level J:211773
hyperactivity J:211773
persistence of hyaloid vascular system J:211773
Nadk2em1(IMPC)J/Nadk2em1(IMPC)J
C57BL/6NJ-Nadk2em1(IMPC)J/J
abnormal embryo size J:211773
abnormal embryo turning J:211773
embryonic lethality prior to tooth bud stage J:211773
preweaning lethality, complete penetrance J:211773
Nadk2tm1a(EUCOMM)Wtsi/Nadk2tm1a(EUCOMM)Wtsi
involves: C57BL/6N * C57BL/6NTac
abnormal liver physiology J:255700
decreased energy expenditure J:255700
decreased fatty acid oxidation J:255700
enlarged liver J:255700
hepatic steatosis J:255700
increased circulating carnitine level J:255700
increased circulating free fatty acids level J:255700
increased circulating lysine level J:255700
increased circulating triglyceride level J:255700
increased liver triglyceride level J:255700
increased lysine level J:255700
increased respiratory quotient J:255700
liver degeneration J:255700
liver fibrosis J:255700
oxidative stress J:255700
pale liver J:255700
Nadk2tm1b(EUCOMM)Wtsi/Nadk2+
C57BL/6N-Nadk2tm1b(EUCOMM)Wtsi/Wtsi
abnormal coat/hair pigmentation J:211773
decreased leukocyte cell number J:211773
Nadk2tm1b(EUCOMM)Wtsi/Nadk2tm1b(EUCOMM)Wtsi
C57BL/6N-Nadk2tm1b(EUCOMM)Wtsi/Wtsi
abnormal placenta morphology J:261316
abnormal trophoblast layer morphology J:261316
lethality throughout fetal growth and development, complete penetrance J:261316
preweaning lethality, complete penetrance J:211773

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/02/2021
MGI 6.16
The Jackson Laboratory