Pold3 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pold3
polymerase (DNA-directed), delta 3, accessory subunit
MGI:1915217

18 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pold3^em1Linl/Pold3⁺ involves: C57BL/6 * DBA/2	abnormal double-strand DNA break repair	J:263620
	arrest of male meiosis	J:263620
	decreased male germ cell number	J:263620
	decreased telomere length	J:263620
	decreased testis weight	J:263620
	increased male germ cell apoptosis	J:263620
	seminiferous tubule degeneration	J:263620
	small testis	J:263620
	spontaneous chromosome breakage	J:263620
Pold3^em1Linl/Pold3^em1Linl involves: C57BL/6 * DBA/2	abnormal embryonic tissue physiology	J:263620
	abnormal trophoblast giant cell proliferation	J:263620
	absent egg cylinders	J:263620
	decreased inner cell mass proliferation	J:263620
	embryonic lethality between implantation and somite formation, complete penetrance	J:263620
Pold3^{tm1b(EUCOMM)Wtsi}/Pold3⁺ C57BL/6N-Pold3^{tm1b(EUCOMM)Wtsi}/Wtsi	increased circulating insulin level	J:211773
Pold3^{tm1b(EUCOMM)Wtsi}/Pold3^{tm1b(EUCOMM)Wtsi} C57BL/6N-Pold3^{tm1b(EUCOMM)Wtsi}/Wtsi	embryonic lethality prior to organogenesis	J:211773
	prenatal lethality prior to heart atrial septation	J:211773
	preweaning lethality, complete penetrance	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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