Crls1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Crls1
cardiolipin synthase 1
MGI:1913836

29 phenotypes from 2 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Crls1^{tm1a(EUCOMM)Wtsi}/Crls1^{tm1a(EUCOMM)Wtsi} C57BL/6N-Crls1^{tm1a(EUCOMM)Wtsi}/Wtsi	abnormal chorion morphology	J:261316
	abnormal trophoblast layer morphology	J:261316
	lethality throughout fetal growth and development, complete penetrance	J:261316
	preweaning lethality, complete penetrance	J:211773
Crls1^tm1Geno/Crls1^tm1Geno Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/Gt(ROSA)26Sor⁺ involves: 129S4/SvJae * C57BL/6	decreased oxygen consumption	J:266083
Crls1^tm1Geno/Crls1^tm1Geno Tg(Adipoq-cre)1Evdr/0 involves: C57BL/6 * FVB/NJ	abnormal brown adipose tissue morphology	J:266083
	abnormal brown adipose tissue physiology	J:266083
	abnormal brown adipose tissue thermogenesis	J:266083
	abnormal brown fat cell morphology	J:266083
	abnormal respiratory electron transport chain	J:266083
	normal behavior/neurological phenotype	J:266083
	decreased adipocyte glucose uptake	J:266083
	decreased epididymal fat pad weight	J:266083
	decreased fat cell mitochondrial DNA content	J:266083
	decreased interscapular fat pad weight	J:266083
	decreased mitochondrial size	J:266083
	decreased oxygen consumption	J:266083
	decreased respiratory quotient	J:266083
	decreased subcutaneous adipose tissue amount	J:266083
	decreased susceptibility to diet-induced obesity	J:266083
	disorganized mitochondrial cristae	J:266083
	normal growth/size/body region phenotype	J:266083
	normal homeostasis/metabolism phenotype	J:266083
	impaired adaptive thermogenesis	J:266083
	increased brown fat cell lipid droplet size	J:266083
	increased fasting circulating glucose level	J:266083
	increased liver weight	J:266083
	insulin resistance	J:266083
Crls1^tm1Geno/Crls1^tm1Geno Tg(Ucp1-cre/ERT2)426Biat/0 involves: C57BL/6N	abnormal brown adipose tissue morphology	J:266083
	normal adipose tissue phenotype	J:266083
	decreased interscapular fat pad weight	J:266083
	decreased mitochondrial size	J:266083
	insulin resistance	J:266083
	normal liver/biliary system phenotype	J:266083

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23