Tg(Ucp1-cre/ERT2)426Biat
Transgene Detail

Summary

• Symbol: Tg(Ucp1-cre/ERT2)426Biat
• Name: transgene insertion 426, Biomodels Austria
• MGI ID: MGI:5498561
• Synonyms: Ucp1-CreER
• Transgene: Tg(Ucp1-cre/ERT2)426Biat Location: unknown
• Alliance: Tg(Ucp1-cre/ERT2)426Biat page

Transgene origin

• Strain of Origin: C57BL/6N

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Ucp1-cre/ERT2)426Biat expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Ucp1

• Mutation details: Sequences encoding a cre/ERT2 fusion protein, Frt-flanked neo cassette, and a polyadenylation signal were inserted into a BAC containing the Ucp1 promoter by recombineering methods. The neo marker was not removed, as the original construct showed more efficient cre activity. The purified construct was microinjected into fertilized C57BL/6N oocytes. Line 426 was established. (J:198491)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ucp1 (species not specified) Summary of all recombinase alleles driven by Ucp1.

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:198491 Rosenwald M, et al., Bi-directional interconversion of brite and white adipocytes. Nat Cell Biol. 2013 Jun;15(6):659-67
• All: 24 reference(s)