Ncstn Phenotype Annotations - Multigenic Genotypes

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ncstn
nicastrin
MGI:1891700

10 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Gt(ROSA)26Sor^{tm1.1(rtTA2SM2)Whsu}/Gt(ROSA)26Sor⁺ Ncstn^tm1.1Akli/Ncstn^tm1.1Akli Tg(tetO-cre)1Jaw/0 involves: 129 129S6/SvEvTac * C57BL/6	hydronephrosis	J:227748
	increased urinary bladder carcinoma incidence	J:227748
	ureter obstruction	J:227748
Ncstn^tm1.1Akli/Ncstn^tm1.1Akli Tet2^tm1.1Iaai/Tet2^tm1.1Iaai Tg(VAV1-cre)1Graf/0 involves: 129S/SvEv * C57BL/6	abnormal common myeloid progenitor cell morphology	J:196407
	abnormal tumor pathology	J:196407
	enlarged spleen	J:196407
	increased leukemia incidence	J:196407
	increased leukocyte cell number	J:196407
	myeloid hyperplasia	J:196407
	premature death	J:196407

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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