99 phenotypes from 6 alleles in 9 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Lgr4Gt(LST020)Byg/Lgr4Gt(LST020)Byg involves: 129P2/OlaHsd * C57BL/6	abnormal anterior eye segment morphology	J:134299
	abnormal canal of Schlemm morphology	J:134299
	abnormal cornea morphology	J:134299
	abnormal corneal epithelium morphology	J:134299
	abnormal corneal stroma morphology	J:134299
	abnormal iridocorneal angle	J:134299
	abnormal lens morphology	J:134299
	abnormal retina morphology	J:134299
	anterior iris synechia	J:134299
	cataract	J:134299
	ciliary body hypoplasia	J:134299
	corneal deposits	J:134299
	corneal epithelium hypoplasia	J:134299
	corneal opacity	J:134299
	corneal vascularization	J:134299
	decreased body weight	J:134299
	decreased cornea thickness	J:134299
	decreased corneal epithelium thickness	J:134299
	decreased corneal stroma thickness	J:134299
	decreased survivor rate	J:134299
	disorganized retina inner nuclear layer	J:134299
	disorganized retina outer nuclear layer	J:134299
	disorganized secondary lens fibers	J:134299
	embryonic growth retardation	J:134299
	hypoplastic trabecular meshwork	J:134299
	increased incidence of corneal inflammation	J:134299
	iris hypoplasia	J:134299
	iris stroma hypoplasia	J:134299
	microphthalmia	J:134299
	mydriasis	J:134299
	retina ganglion cell degeneration	J:134299
	small lens	J:134299
	thin retina inner nuclear layer	J:134299
	thin retina outer nuclear layer	J:134299
Lgr4Gt(pGT0TMpfs)1Wcs/Lgr4+ involves: 129P2/Ola * C57BL/6	perinatal lethality, incomplete penetrance	J:92077
Lgr4Gt(pGT0TMpfs)1Wcs/Lgr4Gt(pGT0TMpfs)1Wcs involves: 129P2/Ola * C57BL/6	abnormal kidney morphology	J:92077
	decreased body weight	J:92077
	decreased kidney weight	J:92077
	decreased liver weight	J:92077
	enlarged testis	J:92077
	enlarged uterus	J:92077
	infertility	J:92077
	perinatal lethality, incomplete penetrance	J:92077
Lgr4Gt(pGT0TMpfs)1Wcs/Lgr4Gt(pGT0TMpfs)1Wcs involves: 129P2/OlaHsd * C57BL/6 * CD-1	abnormal efferent ductules of testis morphology	J:105945
	abnormal epididymal fat pad morphology	J:105945
	abnormal epididymis epithelium morphology	J:105945
	abnormal epididymis morphology	J:105945
	abnormal rete testis morphology	J:105945
	abnormal seminiferous tubule epithelium morphology	J:105945
	abnormal testis morphology	J:105945
	abnormal testis physiology	J:105945
	decreased body size	J:105945
	decreased body weight	J:105945
	decreased epididymal cell proliferation	J:105945
	epididymal cyst	J:105945
	epididymis hypoplasia	J:105945
	male infertility	J:105945
	postnatal lethality, incomplete penetrance	J:105945
	rete testis obstruction	J:105945
	small caput epididymis	J:105945
Lgr4Gt(pU-21)1Kymm/Lgr4Gt(pU-21)1Kymm B6.Cg-Lgr4Gt(pU-21)1Kymm	postnatal lethality, incomplete penetrance	J:121125
Lgr4Gt(pU-21)1Kymm/Lgr4Gt(pU-21)1Kymm CBA.Cg-Lgr4Gt(pU-21)1Kymm	abnormal caput epididymis morphology	J:121125
	abnormal epididymis morphology	J:121125
	abnormal reproductive system morphology	J:121125
	abnormal reproductive system physiology	J:121125
	abnormal seminiferous tubule epithelium morphology	J:121125
	abnormal sperm number	J:121125
	abnormal testis morphology	J:121125
	asthenozoospermia	J:121125
	decreased epididymis weight	J:121125
	dilated rete testis	J:121125
	increased testis weight	J:121125
	male infertility	J:121125
	postnatal growth retardation	J:121125
	postnatal lethality, incomplete penetrance	J:121125
	reduced female fertility	J:121125
Lgr4tm1.1(cre/ERT2)Npa/Lgr4tm1.1(cre/ERT2)Npa involves: C57BL/6	abnormal epidermal stem cell proliferation	J:212415
	abnormal glomerular capsule space morphology	J:212415
	abnormal intestine development	J:212415
	abnormal intestine physiology	J:212415
	abnormal skin development	J:212415
	decreased hair follicle number	J:212415
	dilated renal tubule	J:212415
	kidney cyst	J:212415
	perinatal lethality, complete penetrance	J:212415
	prenatal lethality, incomplete penetrance	J:212415
	normal renal/urinary system phenotype	J:212415
	thin epidermis	J:212415
Lgr4tm1.1Knis/Lgr4tm1.1Knis Tg(Cyp1a1-cre)1Dwi/0 involves: 129P2/OlaHsd * C57BL/6 * CBA	abnormal small intestinal crypt cell proliferation	J:174842
	decreased small intestinal villus size	J:174842
	premature death	J:174842
Lgr4tm1.1Knis/Lgr4tm1.1Knis Tg(KRT5-cre)1Tak/0 involves: 129P2/OlaHsd * C3H * C57BL/6 * SJL	eyelids open at birth	J:126813
	normal growth/size/body region phenotype	J:126813
	normal mortality/aging	J:126813
Lgr4tm1.2Knis/Lgr4+ involves: 129P2/OlaHsd * C57BL/6	perinatal lethality, incomplete penetrance	J:127019
Lgr4tm1.2Knis/Lgr4tm1.2Knis B6.129P2-Lgr4tm1.2Knis	abnormal metanephric mesenchyme morphology	J:186318
	abnormal metanephric ureteric bud development	J:172277
	impaired branching involved in ureteric bud morphogenesis	J:172277
	increased kidney apoptosis	J:186318
	kidney cyst	J:172277
	lethality throughout fetal growth and development, incomplete penetrance	J:172277
	perinatal lethality, complete penetrance	J:172277
	renal hypoplasia	J:172277
	small metanephros	J:172277
Lgr4tm1.2Knis/Lgr4tm1.2Knis involves: 129P2/OlaHsd * C57BL/6	abnormal keratinocyte physiology	J:126813
	abnormal kidney morphology	J:127019
	abnormal nephron morphology	J:127019
	decreased fetal weight	J:127019
	decreased kidney weight	J:127019
	decreased renal glomerulus number	J:127019
	eyelids open at birth	J:126813
	increased circulating creatinine level	J:127019
	lethality throughout fetal growth and development, incomplete penetrance	J:127019
	neonatal lethality, incomplete penetrance	J:127019
	perinatal lethality, incomplete penetrance	J:127019
	polycystic kidney	J:127019
	postnatal growth retardation	J:127019
	premature death	J:127019
	renal hypoplasia	J:127019