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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Lin28a
lin-28 homolog A
MGI:1890546
70 phenotypes from 6 alleles in 10 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background
Annotated Term Reference
Col1a1tm1(tetO-Lin28a)Gqda/Col1a1+
involves: 129S4/SvJae * C57BL/6 * CD-1
abnormal digestive system morphology J:166568
abnormal skeleton morphology J:166568
big ears J:166568
broad face J:166568
coarse hair J:166568
decreased circulating glucose level J:166568
decreased circulating insulin level J:166568
decreased susceptibility to age related obesity J:177113
decreased susceptibility to diet-induced hepatic steatosis J:177113
decreased susceptibility to diet-induced obesity J:177113
decreased total body fat amount J:177113
delayed female fertility J:166568
delayed sexual maturation J:166568
delayed vaginal opening J:166568
improved glucose tolerance J:166568, J:177113
increased body length J:166568
increased body size J:166568
increased body weight J:166568
increased bone mineral content J:166568
increased bone mineral density J:166568
increased cell proliferation J:166568
increased growth rate J:166568
increased hepatocyte proliferation J:166568
increased insulin sensitivity J:166568, J:177113
increased lean body mass J:177113
increased litter size J:166568
liver hyperplasia J:166568
premature death J:166568
normal reproductive system phenotype J:166568
skin hyperplasia J:166568
small pancreatic islets J:166568
thick skin J:166568
Lin28atm1.1Gqda/Lin28atm1.1Gqda
involves: 129S4/SvJae * C57BL/6
abnormal cell physiology J:199720
abnormal glucose homeostasis J:199720
decreased body length J:199720
decreased body size J:199720
decreased body weight J:199720
decreased bone mineral density J:199720
decreased embryo weight J:199720
decreased fetal weight J:199720
decreased total body fat amount J:199720
normal muscle phenotype J:199720
neonatal lethality, incomplete penetrance J:199720
ventricular septal defect J:199720
Lin28atm1.1Gqda/Lin28atm1.1Gqda
involves: 129S4/SvJae * C57BL/6 * FVB
decreased germ cell number J:196313
reduced fertility J:196313
Lin28atm1.2Gqda/Lin28atm1.2Gqda
STOCK Lin28atm1.2Gqda/J
no abnormal phenotype detected J:101977
Lin28atm1Egm/Lin28atm1Egm
involves: 129S/SvEv
decreased birth weight J:166568
postnatal lethality, complete penetrance J:166568
Lin28atm1Egm/Lin28atm1Egm
involves: 129S/SvEv * C57BL/6NTac
decreased body size J:196313
decreased body weight J:196313
decreased circulating follicle stimulating hormone level J:196313
decreased circulating testosterone level J:196313
decreased germ cell number J:196313
decreased litter size J:196313
decreased oocyte number J:196313
decreased ovary weight J:196313
decreased primordial germ cell number J:196313
decreased primordial ovarian follicle number J:196313
oligozoospermia J:196313
reduced female fertility J:196313
reduced male fertility J:196313
reduced male mating frequency J:196313
Lin28atm1Gqda/Lin28atm1.1Gqda
Ndor1Tg(UBC-cre/ERT2)1Ejb/0
involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N
decreased body length J:199720
decreased body size J:199720
normal growth/size/body region phenotype J:199720
Lin28atm1Gqda/Lin28atm1Gqda
Myf5tm1(cre)Mrc/Myf5+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
normal growth/size/body region phenotype J:199720
Lin28atm1Gqda/Lin28atm1Gqda
Myf5tm3(cre)Sor/Myf5+
involves: 129S4/SvJae * C57BL/6 * CD-1
impaired glucose tolerance J:177113
insulin resistance J:177113
Tg(Cdh16-cre)91Igr/0
Tg(EIF1AX-Lin28a)#Gqda/0
involves: 129S4/SvJae * C57BL/6 * ICR
normal neoplasm J:211179
Tg(Ddx4-cre)1Dcas/0
Tg(EIF1AX-Lin28a)#Gqda/0
involves: 129S4/SvJae * C57BL/6 * CD-1 * FVB/N
abnormal kidney mesenchyme morphology J:211179
abnormal proximal convoluted tubule morphology J:211179
delayed kidney development J:211179
enlarged kidney J:211179
increased kidney tumor incidence J:211179
perinatal lethality J:211179
Tg(EIF1AX-Lin28a)#Gqda/0
Foxd1tm1(GFP/cre)Amc/Foxd1+
involves: 129S4/SvJae * C57BL/6
normal neoplasm J:211179
Tg(EIF1AX-Lin28a)#Gqda/0
Tg(Six2-EGFP/cre)1Amc/0
involves: 129S4/SvJae * C57BL/6 * CD-1
kidney cyst J:211179
normal neoplasm J:211179

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory