Prdx5 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Prdx5
peroxiredoxin 5
MGI:1859821

25 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Prdx5^{tm1.1(KOMP)Vlcg}/Prdx5^{tm1.1(KOMP)Vlcg} involves: C57BL/6J * C57BL/6NTac	abnormal cellular respiration	J:271141
	abnormal mitochondrial ATP synthesis coupled electron transport	J:271141
	abnormal nitric oxide homeostasis	J:271141
	abnormal redox activity	J:271141
	decreased oxygen consumption	J:271141
	normal immune system phenotype	J:271141
	increased circulating interleukin-12b level	J:271141
	increased circulating tumor necrosis factor level	J:271141
	increased interleukin-6 secretion	J:271141
	increased interleukin-12b secretion	J:271141
	increased tumor necrosis factor secretion	J:271141
	oxidative stress	J:271141
Prdx5^tm1Dsle/Prdx5^tm1Dsle involves: C57BL/6	abnormal epididymal fat pad morphology	J:294801
	abnormal inguinal fat pad morphology	J:294801
	normal behavior/neurological phenotype	J:294801
	normal homeostasis/metabolism phenotype	J:294801
	impaired glucose tolerance	J:294801
	increased body weight	J:294801
	increased circulating insulin level	J:294801
	increased circulating leptin level	J:294801
	increased liver triglyceride level	J:294801
	increased liver weight	J:294801
	increased susceptibility to diet-induced hepatic steatosis	J:294801
	increased susceptibility to diet-induced obesity	J:294801
	insulin resistance	J:294801
	oxidative stress	J:294801

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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