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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Tlr5
toll-like receptor 5
MGI:1858171
44 phenotypes from 3 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Tg(Vil1-cre)997Gum/?
Tlr5tm1.1Gewr/Tlr5tm1.1Gewr
involves: C57BL/6J * C57BL/6NTac * SJL/J
abnormal colon morphology J:229155
abnormal gut flora balance J:229155
decreased colon length J:229155
enlarged spleen J:229155
increased body weight J:229155
increased circulating cholesterol level J:229155
increased circulating triglyceride level J:229155
increased fasting circulating glucose level J:229155
increased interleukin-1 beta secretion J:229155
increased susceptibility to colitis induced morbidity/mortality J:229155
increased total fat pad weight J:229155
large intestinal inflammation J:229155
polyphagia J:229155
Tlr5tm1.1Gewr/Tlr5tm1.1Gewr
Tg(Itgax-cre,-EGFP)4097Ach/?
involves: C57BL/6J * C57BL/6NTac
abnormal gut flora balance J:229155
decreased total fat pad weight J:229155
normal immune system phenotype J:229155
Tlr5tm1Aki/Tlr5tm1Aki
B6.129P2-Tlr5tm1Aki
decreased interleukin-6 secretion J:112391
decreased interleukin-12b secretion J:112391
decreased susceptibility to bacterial infection J:112391
normal immune system phenotype J:116763
Tlr5tm1Aki/Tlr5tm1Aki
involves: 129P2/OlaHsd
abnormal gut flora balance J:229155
decreased colon length J:229155
enlarged spleen J:229155
increased interleukin-1 beta secretion J:229155
increased susceptibility to colitis induced morbidity/mortality J:229155
Tlr5tm1Aki/Tlr5tm1Aki
involves: 129P2/OlaHsd * C57BL/6
abnormal macrophage physiology J:112671
Tlr5tm1Flv/Tlr5tm1Flv
involves: 129S1/Sv
abnormal leukocyte migration J:171379
Tlr5tm1Flv/Tlr5tm1Flv
involves: 129S1/Sv * C57BL/6
abnormal adipose tissue physiology J:158055
abnormal cytokine secretion J:111778
abnormal dendritic cell physiology J:111778
abnormal eating behavior J:158055
abnormal glucose homeostasis J:158055
abnormal gut flora balance J:158055
abnormal physiological response to xenobiotic J:158055
abnormal response to transplant J:111778
decreased neutrophil cell number J:111778
hepatic steatosis J:158055
hypertension J:158055
increased body weight J:158055
increased circulating cholesterol level J:158055
increased circulating insulin level J:158055
increased circulating triglyceride level J:158055
increased epididymal fat pad weight J:158055
increased susceptibility to autoimmune diabetes J:158055
increased susceptibility to bacterial infection J:111778
increased susceptibility to diet-induced obesity J:158055
increased susceptibility to induced colitis J:158055
increased susceptibility to induced pancreatitis J:158055
increased systemic arterial blood pressure J:158055
increased systemic arterial diastolic blood pressure J:158055
increased systemic arterial systolic blood pressure J:158055
increased total body fat amount J:158055
insulin resistance J:158055
lung inflammation J:111778
obese J:158055
polyphagia J:158055

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory