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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Slc7a8
solute carrier family 7 (cationic amino acid transporter, y+ system), member 8
MGI:1355323
15 phenotypes from 3 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Slc7a8tm1Dgen/Slc7a8tm1Dgen
involves: 129P2/OlaHsd * C57BL/6 		decreased locomotor activity J:101679
decreased susceptibility to pharmacologically induced seizures J:101679
impaired coordination J:101679
Slc7a8tm1Geno/Slc7a8+
involves: 129 * C57BL/6J 		abnormal spiral ligament fibrocyte morphology J:256844
impaired hearing J:256844
Slc7a8tm1Geno/Slc7a8tm1Geno
B6.Cg-Slc7a8tm1Geno 		impaired hearing J:256844
Slc7a8tm1Geno/Slc7a8tm1Geno
involves: 129 * C57BL/6J 		abnormal auditory brainstem response waveform shape J:256844
abnormal spiral ligament fibrocyte morphology J:256844
abnormal spiral ligament morphology J:256844
abnormal strial basal cell morphology J:256844
cochlear ganglion degeneration J:256844
cochlear hair cell degeneration J:256844
decreased prepulse inhibition J:256844
normal homeostasis/metabolism phenotype J:256844
impaired coordination J:256844
impaired hearing J:256844
increased or absent threshold for auditory brainstem response J:256844
Slc7a8tm2b(EUCOMM)Hmgu/Slc7a8+
C57BL/6N-Slc7a8tm2b(EUCOMM)Hmgu/Bay 		decreased circulating fructosamine level J:211773
short tibia J:211773
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory