Tnfsf14 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tnfsf14
tumor necrosis factor (ligand) superfamily, member 14
MGI:1355317

57 phenotypes from 5 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tg(Lck-Tnfsf14)24Yxf/? C57BL/6-Tg(Lck-Tnfsf14)24Yxf	abnormal complement protein level	J:128976
	abnormal glomerular mesangium morphology	J:128976
	abnormal inflammatory response	J:128976
	abnormal intestinal epithelium morphology	J:128976
	abnormal intestine morphology	J:128976
	abnormal liver morphology	J:120962
	abnormal lymph node cell ratio	J:129951
	abnormal renal glomerulus morphology	J:128976
	abnormal T cell physiology	J:120962, J:129951
	colitis	J:129951
	extramedullary hematopoiesis	J:129951
	glomerulonephritis	J:129951
	glomerulosclerosis	J:128976
	hematuria	J:128976
	increased anti-double stranded DNA antibody level	J:129951
	increased anti-nuclear antigen antibody level	J:128976
	increased autoantibody level	J:129951
	increased circulating cholesterol level	J:120962
	increased circulating triglyceride level	J:120962
	increased enterocyte apoptosis	J:128976
	increased IgA level	J:128976
	increased IgG level	J:128976
	increased spleen weight	J:129951
	increased T cell proliferation	J:129951
	increased urine protein level	J:128976
	intestinal inflammation	J:128976
	liver inflammation	J:129951
	lung inflammation	J:129951
	lymph node hyperplasia	J:129951
	myositis	J:129951
	renal glomerular immunoglobulin deposits	J:129951
	small intestinal inflammation	J:120962
	spleen hyperplasia	J:129951
	spontaneous skin ulceration	J:129951
Tnfsf14^tm1Ddy/Tnfsf14^tm1Ddy involves: 129S1/Sv * 129X1/SvJ	abnormal cytotoxic T cell physiology	J:84366
	abnormal T cell activation	J:84366
	decreased T cell proliferation	J:84366
	normal immune system phenotype	J:84366
Tnfsf14^tm1Kpf/Tnfsf14^tm1Kpf B6.129P2-Tnfsf14^tm1Kpf	abnormal chondrocyte morphology	J:294030
	abnormal compact bone morphology	J:294030
	abnormal osteoclast differentiation	J:294030
	abnormal spine curvature	J:294030
	abnormal thoracic vertebrae morphology	J:294030
	abnormal trabecular bone morphology	J:294030
	decreased trabecular bone volume	J:294030
	increased bone trabecular spacing	J:294030
Tnfsf14^tm1Kpf/Tnfsf14^tm1Kpf involves: 129P2/OlaHsd	abnormal gamma-delta T cell morphology	J:169863
Tnfsf14^tm1Kpf/Tnfsf14^tm1Kpf involves: 129P2/OlaHsd * C57BL/6	abnormal T cell subpopulation ratio	J:77250
	decreased cytotoxic T cell cytolysis	J:77250
	decreased interferon-gamma secretion	J:77250
	decreased interleukin-2 secretion	J:77250
	decreased interleukin-4 secretion	J:77250
	decreased interleukin-10 secretion	J:77250
	decreased splenocyte proliferation	J:77250
	decreased T cell proliferation	J:77250
Tnfsf14^tm1Lpc/Tnfsf14^tm1Lpc B6.129X1-Tnfsf14^tm1Lpc	normal immune system phenotype	J:158663
Tnfsf14^tm1Lpc/Tnfsf14^tm1Lpc involves: 129X1/SvJ * C57BL/6	abnormal cytotoxic T cell physiology	J:76414
	decreased cytotoxic T cell cytolysis	J:76414
	decreased inflammatory response	J:107803
	decreased interferon-gamma secretion	J:76414
	decreased tumor necrosis factor secretion	J:76414
Tnfsf14^tm1Wwh/Tnfsf14^tm1Wwh involves: 129 * C57BL/6	increased length of allograft survival	J:75705

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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