Eif2ak4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Eif2ak4
eukaryotic translation initiation factor 2 alpha kinase 4
MGI:1353427

25 phenotypes from 4 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Eif2ak4^m1Btlr/Eif2ak4^m1Btlr C57BL/6J-Eif2ak4^m1Btlr	abnormal macrophage physiology	J:173669
	increased susceptibility to Adenoviridae infection	J:173669
	increased susceptibility to Herpesvirales infection	J:173669
Eif2ak4^tm1.1Dron/Eif2ak4^tm1.1Dron Tg(Nes-cre)1Kln/0 involves: 129S6/SvEvTac * C57BL/6 * SJL	abnormal food preference	J:129841
Eif2ak4^tm1.2Dron/Eif2ak4^tm1.2Dron 129S6/SvEvTac-Eif2ak4^tm1.2Dron	abnormal contextual conditioning behavior	J:100646
	abnormal long-term potentiation	J:100646
	abnormal spatial reference memory	J:100646
Eif2ak4^tm1.2Dron/Eif2ak4^tm1.2Dron involves: 129S6/SvEvTac	abnormal food preference	J:129841
Eif2ak4^tm1.2Dron/Eif2ak4^tm1.2Dron involves: 129S6/SvEvTac * C57BL/6 * CBA	abnormal cytokine secretion	J:120813
	abnormal dendritic cell physiology	J:120813
Eif2ak4^tm1Drc/Eif2ak4^tm1Drc B6.129S6-Eif2ak4^tm1Drc	abnormal circulating amino acid level	J:92545
	normal behavior/neurological phenotype	J:92545
	decreased liver weight	J:92545
	decreased skeletal muscle mass	J:92545
	normal growth/size/body region phenotype	J:92545
	increased litter size	J:92545
	increased susceptibility to induced morbidity/mortality	J:92545
	postnatal growth retardation	J:92545
	postnatal lethality, incomplete penetrance	J:92545
Eif2ak4^tm1Drc/Eif2ak4^tm1Drc involves: 129S6/SvEvTac * C57BL/6	abnormal circulating amino acid level	J:92545
	abnormal eating behavior	J:92545
	decreased litter size	J:78945
	decreased liver weight	J:92545
	decreased skeletal muscle mass	J:92545
	normal homeostasis/metabolism phenotype	J:78945
	increased growth rate	J:92545
	increased litter size	J:92545
	increased susceptibility to weight loss	J:92545
	maternal effect	J:78945
	normal mortality/aging	J:78945, J:92545

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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