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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Foxa2
forkhead box A2
MGI:1347476
55 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
9030622O22Rikem1Eem/9030622O22Rik+
Foxa2tm1.1Khk/Foxa2+
involves: 129P2/OlaHsd * C57BL/6 * CD-1 		abnormal respiratory mucosa goblet cell morphology J:284174
respiratory system inflammation J:284174
Dll1tm1.1Hri/Dll1tm1.1Hri
Foxa2tm3.1(icre)Heli/Foxa2+
involves: 129P2/OlaHsd * C57BL/6 * SJL 		abnormal pancreas development J:184814
Fgf8tm1Mrc/Fgf8tm2Moon
Foxa2tm2.1(cre/Esr1*)Moon/Foxa2+
Not Specified 		normal cardiovascular system phenotype J:143444
Fgfr1tm3.2Cxd/Fgfr1tm3.2Cxd
Fgfr2tm1Dor/Fgfr2tm1Dor
Foxa2tm2.1(cre/Esr1*)Moon/Foxa2+
involves: 129S6/SvEvTac * 129X1/SvJ 		abnormal vascular development J:143444
normal cardiovascular system phenotype J:143444
normal mortality/aging J:143444
Foxa1tm1Khk/Foxa1+
Foxa2tm1Khk/Foxa2tm1Khk
Tg(Pdx1-cre)6Cvw/0
involves: 129 * C57BL/6 * CBA * SJL 		decreased pancreatic beta cell number J:143476
exocrine pancreas hypoplasia J:143476
pancreas hypoplasia J:143476
pancreatic islet hypoplasia J:143476
postnatal lethality, complete penetrance J:143476
Foxa1tm1Khk/Foxa1tm1Khk
Foxa2tm1Khk/Foxa2+
Tg(Pdx1-cre)6Cvw/0
involves: 129 * C57BL/6 * CBA * SJL 		normal endocrine/exocrine gland phenotype J:143476
normal homeostasis/metabolism phenotype J:143476
Foxa1tm1Khk/Foxa1tm1Khk
Foxa2tm1Khk/Foxa2tm1Khk
Tg(Alb1-cre)1Khk/0
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		decreased incidence of tumors by chemical induction J:181296
increased hepatocellular carcinoma incidence J:181296
increased incidence of tumors by chemical induction J:181296
Foxa1tm1Khk/Foxa1tm1Khk
Foxa2tm1Khk/Foxa2tm1Khk
Tg(Pdx1-cre)6Cvw/0
involves: 129 * C57BL/6 * CBA * SJL 		abnormal pancreas development J:143476
abnormal pancreas morphology J:143476
decreased pancreatic beta cell number J:143476
exocrine pancreas hypoplasia J:143476
hyperglycemia J:143476
pancreas hypoplasia J:143476
pancreatic islet hypoplasia J:143476
postnatal lethality, complete penetrance J:143476
Foxa2tm1.1(rtTa)Moon/Foxa2tm1.1(rtTa)Moon
Gt(ROSA)26Sortm1Sor/?
Tg(tetO-cre)1Jaw/?
involves: C57BL/6 * SJL 		no abnormal phenotype detected J:119721
Foxa2tm1Jrt/Foxa2+
Gsctm1Bhr/Gsctm1Bhr
involves: 129 * C57BL/6 * CD-1 		abnormal anterior cardinal vein morphology J:41809
abnormal brain morphology J:41809
abnormal dorsal aorta morphology J:41809
abnormal dorsal-ventral axis patterning J:41809
abnormal embryo development J:41809
abnormal first pharyngeal arch artery morphology J:41809
abnormal first pharyngeal arch morphology J:41809
abnormal forebrain development J:41809
abnormal heart development J:41809
abnormal heart looping J:41809
abnormal neural tube morphology J:41809
abnormal notochord morphology J:41809
abnormal optic vesicle formation J:41809
abnormal pharyngeal arch morphology J:41809
abnormal pharynx morphology J:41809
abnormal second pharyngeal arch morphology J:41809
absent dorsal mesocardium J:41809
absent optic vesicle J:41809
decreased embryonic neuroepithelium thickness J:41809
decreased forebrain size J:41809
decreased hindbrain size J:41809
decreased somite size J:41809
decreased spinal cord size J:41809
embryonic growth arrest J:41809
embryonic growth retardation J:41809
embryonic lethality during organogenesis, complete penetrance J:41809
small first pharyngeal arch J:41809
small pharynx J:41809
small second pharyngeal arch J:41809
Foxa2tm1Jrt/Foxa2+
Nodaltm1Rob/Nodal+
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ 		abnormal direction of embryo turning J:32935
delayed embryo turning J:32935
situs ambiguus J:32935
Foxa2tm1Jrt/Foxa2tm1Jrt
Gsctm1Bhr/Gsc+
involves: 129/Sv * C57BL/6 * CD-1 		abnormal embryo development J:41809
decreased embryo size J:41809
Foxa2tm1Jrt/Foxa2tm1Jrt
Gsctm1Bhr/Gsctm1Bhr
involves: 129/Sv * C57BL/6 * CD-1 		abnormal embryo development J:41809
decreased embryo size J:41809
Foxa2tm2.1(cre/Esr1*)Moon/Foxa2+
Nkx2-5tm1Krc/Nkx2-5tm1Krc
involves: 129 * C57BL/6 		normal cardiovascular system phenotype J:214093
Foxa2tm2.1(cre/Esr1*)Moon/Foxa2tm2.1(cre/Esr1*)Moon
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
involves: 129S4/SvJaeSor 		no abnormal phenotype detected J:130990
Gt(ROSA)26Sortm1.1(Maml1/EGFP)Hri/?
Foxa2tm3.1(icre)Heli/Foxa2+
involves: 129P2/OlaHsd * C57BL/6 * SJL 		abnormal pancreas development J:184814
abnormal pancreatic beta cell differentiation J:184814
Hes1tm1Kag/Hes1tm1Kag
Foxa2tm3.1(icre)Heli/Foxa2+
involves: 129P2/OlaHsd * C57BL/6 * CBA 		abnormal pancreas development J:184814
abnormal pancreatic beta cell differentiation J:184814
Mib1tm2Kong/Mib1tm2Kong
Foxa2tm3.1(icre)Heli/Foxa2+
involves: 129P2/OlaHsd * C57BL/6 * SJL 		abnormal pancreas development J:184814
abnormal pancreatic beta cell differentiation J:184814
absent pancreatic duct J:184814
NipblGt(EUCE313f02)1.1Hmgu/Nipbl+
Foxa2tm1(cre)Heli/Foxa2+
involves: 129P2/OlaHsd * 129S2/SvPas * CD-1 		atrial septal defect J:236978
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/30/2024
MGI 6.23 		The Jackson Laboratory