Irs4 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Irs4
insulin receptor substrate 4
MGI:1338009

17 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Irs1^tm1Jos/Irs1^tm1Jos Irs4^tm1Lhd/Y involves: 129S2/SvPas * 129S4/SvJae * C57BL/6	impaired glucose tolerance	J:80976
	increased circulating insulin level	J:80976
	insulin resistance	J:80976
	postnatal growth retardation	J:80976
Irs1^tm1Jos/Irs1^tm1Jos Irs4^tm1Lhd/Irs4^tm1Lhd involves: 129S2/SvPas * 129S4/SvJae * C57BL/6	impaired glucose tolerance	J:80976
	increased circulating insulin level	J:80976
	insulin resistance	J:80976
	postnatal growth retardation	J:80976
Irs2^tm2Mfw/Irs2^tm2Mfw Irs4^tm1.1Mfw/Y Lepr^tm3(cre)Mgmj/Lepr⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	normal growth/size/body region phenotype	J:221293
	normal homeostasis/metabolism phenotype	J:221293
Irs2^tm2Mfw/Irs2^tm2Mfw Irs4^tm1.1Mfw/Y Tg(Nes-cre)1Kln/? involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	abnormal adipose tissue amount	J:221293
	abnormal glucose homeostasis	J:221293
	decreased basal metabolism	J:221293
	decreased oxygen consumption	J:221293
	hepatic steatosis	J:221293
	impaired glucose tolerance	J:221293
	increased body weight	J:221293
	increased brown fat cell lipid droplet size	J:221293
	increased circulating glucose level	J:221293
	increased circulating insulin level	J:221293
	increased circulating leptin level	J:221293
	increased fasting circulating glucose level	J:221293
	increased food intake	J:221293
	insulin resistance	J:221293

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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