Cbfa2t2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cbfa2t2
CBFA2/RUNX1 translocation partner 2
MGI:1333833

25 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cbfa2t2^em1Dare/Cbfa2t2^em1Dare C57BL/6-Cbfa2t2^em1Dare	abnormal epigenetic regulation of gene expression	J:233954
	abnormal primordial germ cell morphology	J:233954
	abnormal spermatogenesis	J:233954
	absent ovarian follicles	J:233954
	asthenozoospermia	J:233954
	decreased male germ cell number	J:233954
	decreased primordial germ cell number	J:233954
	decreased testis weight	J:233954
	female infertility	J:233954
	impaired binding of sperm to zona pellucida	J:233954
	infertility	J:233954
	male infertility	J:233954
	oligozoospermia	J:233954
	ovary hypoplasia	J:233954
	small testis	J:233954
Cbfa2t2^tm1Swh/Cbfa2t2^tm1Swh either: B6.129S6-Cbfa2t2^tm1Swh or (involves: 129S6/SvEvTac * C57BL/6)	abnormal intestinal enteroendocrine cell morphology	J:102172
	abnormal intestinal epithelium morphology	J:102172
	abnormal intestinal goblet cell morphology	J:102172
	abnormal small intestine morphology	J:102172
	decreased body length	J:102172
	decreased body size	J:102172
	decreased fetal weight	J:102172
	decreased Paneth cell number	J:102172
	postnatal lethality, incomplete penetrance	J:102172
	small intestinal inflammation	J:102172

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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