Blm Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Blm
Bloom syndrome, RecQ like helicase
MGI:1328362

25 phenotypes from 6 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Blm^tm1Ches/Blm^tm1Ches involves: 129S6/SvEvTac * NIH Black Swiss	abnormal apoptosis	J:50843
	abnormal blood volume	J:50843
	abnormal cell morphology	J:50843
	abnormal erythrocyte morphology	J:50843
	abnormal erythropoiesis	J:50843
	abnormal proerythroblast morphology	J:50843
	abnormal reticulocyte morphology	J:50843
	anemia	J:50843
	decreased embryo size	J:50843
	embryonic growth retardation	J:50843
	lethality throughout fetal growth and development, complete penetrance	J:50843
	macrocytosis	J:50843
Blm^tm1Ches/Blm^tm3Brd involves: 129S/SvEv * C57BL/6 * NIH Black Swiss	increased lymphoma incidence	J:86827
	increased tumor incidence	J:86827
	postnatal growth retardation	J:86827
Blm^tm1Ches/Blm^tm4Ches Tg(Hsp70-1-cre)6Arge/0 involves: 129S6/SvEvTac * C57BL/6 * CBA	increased mammary gland tumor incidence	J:112115
Blm^tm1Ches/Blm^tm4Ches Tg(KLK3-cre)1Ches/0 involves: 129S6/SvEvTac	increased mammary gland tumor incidence	J:112115
Blm^tm1Ches/Blm^tm4Ches Tg(LGB-cre)74Acl/0 involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL	increased mammary adenocarcinoma incidence	J:112115
Blm^tm1Grdn/Blm⁺ involves: 129P2/OlaHsd * Black Swiss	chromosome breakage	J:79058
Blm^tm1Grdn/Blm⁺ involves: 129P2/OlaHsd * Black Swiss	increased incidence of induced tumors	J:79058
Blm^tm2Brd/Blm^tm2Brd involves: 129S7/SvEvBrd * C57BL/6	prenatal lethality	J:66261
Blm^tm2Brd/Blm^tm3Brd involves: 129S7/SvEvBrd * C57BL/6	no abnormal phenotype detected	J:66261
Blm^tm3Brd/Blm^tm3Brd involves: 129S7/SvEvBrd * C57BL/6	decreased IgM level	J:66261
	increased lymphoma incidence	J:66261
	increased tumor incidence	J:66261
Blm^tm3Ches/Blm^tm3Ches involves: 129S6/SvEvTac * NIH Black Swiss	abnormal erythrocyte morphology	J:86827
	anisopoikilocytosis	J:86827
	decreased embryo size	J:86827
	embryonic lethality, complete penetrance	J:86827
	pallor	J:86827
	postnatal growth retardation	J:86827

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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