79 phenotypes from 4 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Wfs1tm1.1Bedel/Wfs1tm1.1Bedel involves: C57BL/6N	abnormal inner ear vestibule morphology	J:342760
	abnormal postural reflex	J:342760
	absent distortion product otoacoustic emissions	J:342760
	absent outer hair cell stereocilia	J:342760
	circling	J:342760
	deafness	J:342760
	decreased endocochlear potential	J:342760
	fused inner hair cell stereocilia	J:342760
	fused vestibular hair cell stereocilia	J:342760
	head bobbing	J:342760
	impaired coordination	J:342760
	impaired righting response	J:342760
	impaired swimming	J:342760
	increased or absent threshold for auditory brainstem response	J:342760
	normal nervous system phenotype	J:342760
	stria vascularis degeneration	J:342760
	vestibular hair cell degeneration	J:342760
Wfs1tm1Koks/Wfs1+ 129S6/SvEvTac-Wfs1tm1Koks	decreased body weight	J:157967
Wfs1tm1Koks/Wfs1+ involves: 129S6/SvEvTac * C57BL/6	decreased body weight	J:157967
	impaired behavioral response to addictive substance	J:145548
	impaired glucose tolerance	J:145548
Wfs1tm1Koks/Wfs1tm1Koks 129S6/SvEvTac-Wfs1tm1Koks	abnormal blood homeostasis	J:221943
	abnormal seminiferous tubule epithelium morphology	J:157127
	abnormal seminiferous tubule morphology	J:157127
	abnormal sperm flagellum morphology	J:157127
	abnormal sperm head morphology	J:157127
	abnormal spermatogonia morphology	J:157127
	abnormal thyroid follicle morphology	J:221941
	abnormal thyroid gland morphology	J:221941
	decreased body size	J:157967
	decreased body weight	J:157967, J:221941, J:221943
	decreased circulating glucose level	J:221943
	decreased circulating insulin level	J:221943
	decreased circulating leptin level	J:221941
	decreased copulatory plug deposition	J:157127
	decreased food intake	J:221941
	decreased male germ cell number	J:157127
	decreased Sertoli cell number	J:157127
	normal homeostasis/metabolism phenotype	J:157127
	hyperglycemia	J:221943
	impaired glucose tolerance	J:157967, J:221943
	increased circulating insulin-like growth factor I level	J:157967
	increased oxygen consumption	J:221941
	increased sperm motility	J:157127
	increased vertical activity	J:221941
	reduced male fertility	J:157127
	slow postnatal weight gain	J:221943
	weight loss	J:221941, J:221943
Wfs1tm1Koks/Wfs1tm1Koks involves: 129S6/SvEvTac * C57BL/6	abnormal behavioral response to addictive substance	J:145548
	abnormal cued conditioning behavior	J:145548
	abnormal eating behavior	J:145548
	abnormal spatial learning	J:145548
	abnormal vocalization	J:145548
	analgesia	J:145548
	normal behavior/neurological phenotype	J:145548
	decreased body size	J:145548, J:157967
	decreased body weight	J:145548, J:150666, J:157967
	decreased exploration in new environment	J:145548
	decreased locomotor activity	J:145548
	decreased vertical activity	J:145548
	impaired glucose tolerance	J:145548, J:157967
	impaired swimming	J:145548
	increased anxiety-related response	J:150666
	increased circulating corticosterone level	J:145548
	increased locomotor activity	J:145548
	increased thigmotaxis	J:150666
	prenatal lethality, incomplete penetrance	J:145548
	slow postnatal weight gain	J:145548
Wfs1tm1Koks/Wfs1tm1Koks involves: 129S6/SvEvTac * C57BL/6J	abnormal inner hair cell stereociliary bundle morphology	J:342760
	cochlear outer hair cell degeneration	J:342760
	impaired hearing	J:342760
	increased or absent threshold for auditory brainstem response	J:342760
Wfs1tm1Perm/Wfs1tm1Perm Tg(Ins2-cre)23Herr/0 involves: 129X1/SvJ * C57BL/6J * CBA/J	abnormal glucose homeostasis	J:104712
	abnormal pancreatic beta cell physiology	J:104712
	abnormal pancreatic islet morphology	J:104712
	decreased body weight	J:104712
	decreased circulating insulin level	J:104712
	decreased insulin secretion	J:104712
	decreased pancreatic beta cell mass	J:104712
	decreased pancreatic beta cell number	J:104712
	disorganized pancreatic islets	J:104712
	hyperglycemia	J:104712
	impaired glucose tolerance	J:104712
Wfs1tm1Yoka/Wfs1tm1Yoka B6.Cg-Wfs1tm1Yoka	abnormal pancreas secretion	J:90420
	decreased circulating insulin level	J:90420
	decreased pancreatic beta cell number	J:90420
	impaired glucose tolerance	J:90420
	increased glucagon secretion	J:90420
Wfs1tm1Yoka/Wfs1tm1Yoka B6J.129-Wfs1tm1Yoka	abnormal associative learning	J:136108
	abnormal defecation	J:136108
	abnormal social investigation	J:136108
	abnormal spatial learning	J:136108
	enhanced active avoidance behavior	J:136108
	enhanced passive avoidance behavior	J:136108
	increased coping response	J:136108
Wfs1tm1Yoka/Wfs1tm1Yoka involves: 129/Sv * C57BL/6	decreased pancreatic beta cell number	J:90420
	increased circulating glucose level	J:90420
	increased glucagon secretion	J:90420