Tnfrsf1b Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tnfrsf1b
tumor necrosis factor receptor superfamily, member 1b
MGI:1314883

31 phenotypes from 5 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tnfrsf1b^tm1.1Gkl/Tnfrsf1b^tm1.1Gkl Tg(Col6a1-cre)1Gkl/0 involves: C57BL/6 * C57BL/6J * CBA	no abnormal phenotype detected	J:264147
Tnfrsf1b^tm1.2Gkl/Tnfrsf1b^tm1.2Gkl involves: C57BL/6 * C57BL/6J	no abnormal phenotype detected	J:264147
Tnfrsf1b^{tm1a(EUCOMM)Wtsi}/Tnfrsf1b^{tm1a(EUCOMM)Wtsi} C57BL/6N-Tnfrsf1b^{tm1a(EUCOMM)Wtsi}/Ics	decreased circulating creatinine level	J:165965
	decreased grip strength	J:165965
	decreased locomotor activity	J:165965
	decreased T cell number	J:165965
Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx B6.129S7-Tnfrsf1b^tm1Imx	abnormal blood gas level	J:143836
	abnormal lung compliance	J:143836
	decreased systemic arterial blood pressure	J:143836
	normal respiratory system phenotype	J:143836
	normal skeleton phenotype	J:135519
Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx involves: 129S7/SvEvBrd * C57BL/6	abnormal glutamate-mediated receptor currents	J:152590
	decreased susceptibility to dopaminergic neuron neurotoxicity	J:78637
	normal homeostasis/metabolism phenotype	J:59056
	increased circulating tumor necrosis factor level	J:45147
	increased inflammatory response	J:45147
	increased skin papilloma incidence	J:89088
	lung inflammation	J:120174
	microgliosis	J:112713
Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm B6.129S2-Tnfrsf1b^tm1Mwm	abnormal sleep pattern	J:103266
Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm B6.129S2-Tnfrsf1b^tm1Mwm	impaired central nervous system regeneration	J:71178
Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm B6.129S2-Tnfrsf1b^tm1Mwm/J	decreased interferon-gamma secretion	J:107039
	decreased interleukin-2 secretion	J:107039
	decreased T cell proliferation	J:107039
	normal immune system phenotype	J:288523
Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm involves: 129S2/SvPas * C57BL/6	decreased susceptibility to bacterial infection	J:50903
	increased susceptibility to experimental autoimmune encephalomyelitis	J:115225
	increased susceptibility to parasitic infection	J:114203
Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm involves: 129S2/SvPas * C57BL/6J	abnormal immune system physiology	J:21815
	increased susceptibility to bacterial infection	J:21815
Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm involves: 129S2/SvPas * C57BL/6J * NOD	decreased susceptibility to autoimmune diabetes	J:64051
	periinsulitis	J:64051

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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