Kcnq2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Kcnq2
potassium voltage-gated channel, subfamily Q, member 2
MGI:1309503

30 phenotypes from 8 alleles in 11 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Emx1^tm1(cre)Krj/? Kcnq2^tm1.1Avtz/Kcnq2^tm1.1Avtz involves: 129S2/SvPas * C57BL/6	abnormal action potential	J:208109
	abnormal afterhyperpolarization	J:208109
	abnormal brain wave pattern	J:208109
	abnormal hippocampus morphology	J:208109
	abnormal nervous system electrophysiology	J:208109
	postnatal lethality, incomplete penetrance	J:208109
	premature death	J:208109
	tonic-clonic seizures	J:208109
Kcnq2^Nmf134/Kcnq2⁺ C57BL/6J-Kcnq2^Nmf134	abnormal seizure response to electrical stimulation	J:136510
	increased susceptibility to pharmacologically induced seizures	J:136510
	normal nervous system phenotype	J:136510
Kcnq2^Nmf134/Kcnq2⁺ C57BL/6J-Kcnq2^Nmf134/J	abnormal seizure response to electrical stimulation	J:82238
Kcnq2^Nmf134/Kcnq2^Nmf134 C57BL/6J-Kcnq2^Nmf134/J	abnormal seizure response to electrical stimulation	J:82238
Kcnq2^tm1.1Lvi/Kcnq2⁺ 129-Kcnq2^tm1.1Lvi/Lvi	abnormal primary motor cortex morphology	J:298666
	abnormal somatosensory cortex morphology	J:298666
	normal behavior/neurological phenotype	J:298666
	decreased exploration in new environment	J:298666
	impaired spatial learning	J:298666
	increased corpus callosum size	J:298666
	increased superior colliculus size	J:298666
	megacephaly	J:298666
	premature death	J:298666
	tonic-clonic seizures	J:298666
Kcnq2^tm1.1Naas/Kcnq2⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal seizure response to electrical stimulation	J:154582
Kcnq2^tm1.1Naas/Kcnq2^tm1.1Naas B6.129-Kcnq2^tm1.1Naas	decreased body size	J:154582
	neonatal lethality, incomplete penetrance	J:154582
	premature death	J:154582
	tonic-clonic seizures	J:154582
Kcnq2^tm1.1Naas/Kcnq2^tm1.1Naas FVB.129-Kcnq2^tm1.1Naas	decreased body size	J:154582
	postnatal lethality, incomplete penetrance	J:154582
	premature death	J:154582
	prenatal lethality, incomplete penetrance	J:154582
	seizures	J:154582
Kcnq2^tm1.1Naas/Kcnq2^tm1.1Naas involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal neuron physiology	J:154582
	prenatal lethality, incomplete penetrance	J:154582
	seizures	J:154582
Kcnq2^tm1Dgen/Kcnq2⁺ B6.129P2-Kcnq2^tm1Dgen/J	decreased prepulse inhibition	J:161844
Kcnq2^tm1Dgen/Kcnq2⁺ involves: 129P2/OlaHsd * C57BL/6	increased susceptibility to pharmacologically induced seizures	J:101679
Kcnq2^tm1Dgen/Kcnq2^tm1Dgen B6.129P2-Kcnq2^tm1Dgen/J	abnormal afterhyperpolarization	J:142688
Kcnq2^tm1Dgen/Kcnq2^tm1Dgen involves: 129P2/OlaHsd * C57BL/6	preweaning lethality, incomplete penetrance	J:101679
Kcnq2^tm1Hsa/Kcnq2⁺ involves: 129P2/OlaHsd * C57BL/6	normal behavior/neurological phenotype	J:62797
	increased susceptibility to pharmacologically induced seizures	J:62797
	normal reproductive system phenotype	J:62797
Kcnq2^tm1Hsa/Kcnq2^tm1Hsa involves: 129P2/OlaHsd * C57BL/6	atelectasis	J:62797
	neonatal lethality, complete penetrance	J:62797
	normal nervous system phenotype	J:62797
Kcnq2^tm2.1Snhr/Kcnq2⁺ B6.Cg-Kcnq2^tm2.1Snhr	abnormal nervous system electrophysiology	J:213443
Kcnq2^tm2.1Snhr/Kcnq2⁺ B6.Cg-Kcnq2^tm2.1Snhr	clonic seizures	J:213443
Kcnq2^tm2.1Snhr/Kcnq2^tm2.1Snhr B6.Cg-Kcnq2^tm2.1Snhr	abnormal nervous system electrophysiology	J:213443
	normal behavior/neurological phenotype	J:213443
	clonic seizures	J:213443
Kcnq2^tm3.1Snhr/Kcnq2⁺ B6.Cg-Kcnq2^tm3.1Snhr	clonic seizures	J:213443
Kcnq2^tm3.1Snhr/Kcnq2^tm3.1Snhr B6.Cg-Kcnq2^tm3.1Snhr	neonatal lethality, complete penetrance	J:213443

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