Cdk6 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cdk6
cyclin dependent kinase 6
MGI:1277162

29 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Cdk2^tm1Sgo/Cdk2^tm1Sgo Cdk4^tm1Bbd/Cdk4^tm1Bbd Cdk6^tm1Bbd/Cdk6^tm1Bbd involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal common myeloid progenitor cell morphology	J:124678
	decreased cell proliferation	J:124678
	decreased embryo size	J:124678
	decreased myocardial fiber number	J:124678
	embryonic lethality during organogenesis, incomplete penetrance	J:124678
	lethality throughout fetal growth and development, complete penetrance	J:124678
	liver hypoplasia	J:124678
	thin ventricular wall	J:124678
Cdk2^tm1Sgo/Cdk2^tm1Sgo Cdk6^tm1Bbd/Cdk6^tm1Bbd involves: 129S1/Sv * 129X1/SvJ * CD-1	abnormal gametogenesis	J:92529
	abnormal oogenesis	J:92529
	abnormal spermatogenesis	J:92529
	infertility	J:92529
Cdk4^tm1Bbd/Cdk4^tm1Bbd Cdk6^tm1Bbd/Cdk6^tm1Bbd involves: 129S1/Sv * 129X1/SvJ * CD-1 * ICR	abnormal erythrocyte morphology	J:92529
	decreased embryo size	J:92529
	decreased erythrocyte cell number	J:92529
	decreased hematopoietic stem cell number	J:92529
	extramedullary hematopoiesis	J:92529
	lethality throughout fetal growth and development, incomplete penetrance	J:92529
	liver hypoplasia	J:92529
	neonatal lethality, complete penetrance	J:92529
Cdk6^tm1Bbd/Cdk6^tm1Bbd Kras^tm1Bbd/Kras⁺ Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a^{tm1(cre/ERT2)Bbd} involves: 129S1/Sv * 129X1/SvJ	increased adenoma incidence	J:161780
	increased lung non-small cell carcinoma incidence	J:161780
	premature death	J:161780
Cdk6^tm1Phin/Cdk6⁺ Tg(Lck-Akt1*E40K)E-3Pnt/0 involves: 129S4/SvJae	decreased tumor-free survival time	J:144975
	increased T cell derived lymphoma incidence	J:144975
Cdk6^tm1Phin/Cdk6^tm1Phin Tg(Lck-Akt1*E40K)E-3Pnt/0 involves: 129S4/SvJae	abnormal T cell differentiation	J:144975
	normal neoplasm	J:144975
Cdk6^tm2.1Phin/Cdk6^tm2.1Phin Il2ra^tm1Dw/Il2ra^tm1Dw involves: 129S4/SvJae * C57BL/6 * FVB/N	normal hematopoietic system phenotype	J:174697
	increased CD4-positive, alpha-beta T cell number	J:174697
	increased CD8-positive, alpha-beta T cell number	J:174697
	increased hematopoietic stem cell number	J:174697

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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