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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Cdk6
cyclin-dependent kinase 6
MGI:1277162
28 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background
Annotated Term Reference
Cdk2tm1Sgo/Cdk2tm1Sgo
Cdk4tm1Bbd/Cdk4tm1Bbd
Cdk6tm1Bbd/Cdk6tm1Bbd
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
abnormal common myeloid progenitor cell morphology J:124678
decreased cell proliferation J:124678
decreased embryo size J:124678
decreased myocardial fiber number J:124678
embryonic lethality during organogenesis, incomplete penetrance J:124678
lethality throughout fetal growth and development, complete penetrance J:124678
liver hypoplasia J:124678
thin ventricular wall J:124678
Cdk2tm1Sgo/Cdk2tm1Sgo
Cdk6tm1Bbd/Cdk6tm1Bbd
involves: 129S1/Sv * 129X1/SvJ * CD-1
abnormal gametogenesis J:92529
abnormal oogenesis J:92529
abnormal spermatogenesis J:92529
infertility J:92529
Cdk4tm1Bbd/Cdk4tm1Bbd
Cdk6tm1Bbd/Cdk6tm1Bbd
involves: 129S1/Sv * 129X1/SvJ * CD-1 * ICR
abnormal erythrocyte morphology J:92529
decreased embryo size J:92529
decreased erythrocyte cell number J:92529
decreased hematopoietic stem cell number J:92529
extramedullary hematopoiesis J:92529
lethality throughout fetal growth and development, incomplete penetrance J:92529
liver hypoplasia J:92529
neonatal lethality, complete penetrance J:92529
Cdk6tm1Bbd/Cdk6tm1Bbd
Krastm1Bbd/Kras+
Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
involves: 129S1/Sv * 129X1/SvJ
increased adenoma incidence J:161780
increased lung non-small cell carcinoma incidence J:161780
premature death J:161780
Cdk6tm1Phin/Cdk6+
Tg(Lck-Akt1*E40K)E-3Pnt/0
involves: 129S4/SvJae
increased T cell derived lymphoma incidence J:144975
premature death J:144975
Cdk6tm1Phin/Cdk6tm1Phin
Tg(Lck-Akt1*E40K)E-3Pnt/0
involves: 129S4/SvJae
abnormal T cell differentiation J:144975
normal neoplasm J:144975
Cdk6tm2.1Phin/Cdk6tm2.1Phin
Il2ratm1Dw/Il2ratm1Dw
involves: 129S4/SvJae * C57BL/6 * FVB/N
normal hematopoietic system phenotype J:174697
increased CD4-positive, alpha beta T cell number J:174697
increased CD8-positive, alpha-beta T cell number J:174697
increased hematopoietic stem cell number J:174697

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/23/2020
MGI 6.15
The Jackson Laboratory