Chek1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Chek1
checkpoint kinase 1
MGI:1202065

24 phenotypes from 4 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Chek1^tm1Jmr/Chek1⁺ Tg(Wap-cre)11738Mam/0 involves: C57BL/6	increased cell proliferation	J:91266
Chek1^tm1Jmr/Chek1⁺ Tg(Dct-lacZ)A12Jkn/0 Tg(Tyr-cre)1Lru/Y involves: C57BL/6 * CBA * DBA/2	abnormal melanoblast morphology	J:265850
	normal pigmentation phenotype	J:265850
Chek1^tm1Jmr/Chek1^tm1Jmr Tg(Dct-lacZ)A12Jkn/0 Tg(Tyr-cre)1Lru/Y involves: C57BL/6 * CBA * DBA/2	abnormal DNA replication	J:265850
	abnormal melanoblast morphology	J:265850
Chek1^tm1Jmr/Chek1^tm1Jmr Tg(Tyr-cre)1Lru/Y involves: C57BL/6 * DBA/2	abnormal epidermal melanocyte morphology	J:265850
	abnormal hair follicle melanocyte morphology	J:265850
	absent coat pigmentation	J:265850
	decreased melanocyte number	J:265850
Chek1^tm1Jmr/Chek1^tm1Jmr Tg(Wap-cre)11738Mam/0 involves: C57BL/6	abnormal apoptosis	J:91266
	abnormal lactation	J:91266
	abnormal mammary gland growth during pregnancy	J:91266
	decreased cell proliferation	J:91266
Chek1^tm1Mkt/Chek1^tm1Mkt involves: 129P2/OlaHsd * C57BL/6J	abnormal cell cycle checkpoint function	J:62918
	abnormal cell nucleus morphology	J:62918
	abnormal inner cell mass proliferation	J:62918
	absent inner cell mass proliferation	J:62918
	embryonic lethality between implantation and somite formation, complete penetrance	J:62918
	increased inner cell mass apoptosis	J:62918
Chek1^tm1Sje/Chek1⁺ Not Specified	normal neoplasm	J:62919
Chek1^tm1Sje/Chek1^tm1Sje Not Specified	abnormal cell cycle checkpoint function	J:62919
	decreased cell proliferation	J:62919
	embryonic lethality before implantation, complete penetrance	J:62919
	failure of blastocyst to hatch from the zona pellucida	J:62919
	increased embryonic tissue cell apoptosis	J:62919
Chek1^tm2.1Sje/Chek1⁺ Tg(MMTV-cre)#Mam/0 involves: FVB	abnormal mammary gland alveolus morphology	J:162126
	abnormal mammary gland morphology	J:162126
	normal neoplasm	J:162126
Chek1^tm2.1Sje/Chek1^tm2.1Sje Tg(MMTV-cre)#Mam/0 involves: FVB	abnormal mammary gland alveolus morphology	J:162126
	abnormal mammary gland morphology	J:162126
	normal neoplasm	J:162126

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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