Chek1^tm2.1Sje
Targeted Allele Detail

Summary

• Symbol: Chek1^tm2.1Sje
• Name: checkpoint kinase 1; targeted mutation 2.1, Stephen J Elledge
• MGI ID: MGI:4818574
• Synonyms: Chk1^Co, CHK1^flox
• Gene: Chek1 Location: Chr9:36619935-36637897 bp, - strand Genetic Position: Chr9, 20.67 cM, cytoband A5.3
• Alliance: Chek1^tm2.1Sje page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:162126
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted upstream of exon 2, and an additional loxP site was inserted downstream of exon 2. Cre mediated recombination removed the neo cassette leaving exon 2 floxed. (J:62919)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chek1 Mutation: 41 strains or lines available

References

• Original: J:62919 Liu Q, et al., Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. Genes Dev. 2000 Jun 15;14(12):1448-59
• All: 4 reference(s)