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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Chek1tm2.1Sje
targeted mutation 2.1, Stephen J Elledge
MGI:4818574
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Chek1tm2.1Sje/Chek1+
Trp53tm1Brn/Trp53tm1Brn
Tg(MMTV-cre)#Mam/0 		involves: 129P2/OlaHsd * FVB MGI:4818610
cn2
 		Chek1tm2.1Sje/Chek1tm2.1Sje
Trp53tm1Brn/Trp53tm1Brn
Tg(MMTV-cre)#Mam/0 		involves: 129P2/OlaHsd * FVB MGI:4818615
cn3
 		Chek1tm2.1Sje/Chek1tm2.1Sje
Trp53tm1Brn/Trp53+
Tg(MMTV-cre)#Mam/0 		involves: 129P2/OlaHsd * FVB MGI:4818618
cn4
 		Chek1tm2.1Sje/Chek1+
Trp53tm1Brn/Trp53+
Tg(MMTV-cre)#Mam/0 		involves: 129P2/OlaHsd * FVB MGI:4818619
cn5
 		Chek1tm2.1Sje/Chek1+
Tg(MMTV-cre)#Mam/0 		involves: FVB MGI:4818608
cn6
 		Chek1tm2.1Sje/Chek1tm2.1Sje
Tg(MMTV-cre)#Mam/0 		involves: FVB MGI:4818609


Genotype
MGI:4818610
cn1
Allelic
Composition		 Chek1tm2.1Sje/Chek1+
Trp53tm1Brn/Trp53tm1Brn
Tg(MMTV-cre)#Mam/0
Genetic
Background		 involves: 129P2/OlaHsd * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chek1tm2.1Sje mutation (0 available); any Chek1 mutation (41 available)
Tg(MMTV-cre)#Mam mutation (0 available)
Trp53tm1Brn mutation (18 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary gland tumor incidence ( J:162126 )
• 7 of 11 mice develop mammary gland tumors with a latency of 9 months unlike wild-type mice
decreased tumor incidence ( J:162126 )
• mice develop fewer tumors than in Trp53tm1Brn Tg(MMTV-cre)Mam homozygotes

endocrine/exocrine glands
abnormal mammary gland alveolus morphology ( J:162126 )
• at 12 months fewer alveoli are found within the mammary glands compared to in wild-type mice
increased mammary gland tumor incidence ( J:162126 )
• 7 of 11 mice develop mammary gland tumors with a latency of 9 months unlike wild-type mice
mammary gland hyperplasia ( J:162126 )
• mammary glands exhibit multifocal hyperplasia unlike in wild-type mice that are more uniform than in Chek1tm2.1Sje Trp53tm1Brn Tg(MMTV-cre)Mam heterozygotes

integument
abnormal mammary gland alveolus morphology ( J:162126 )
• at 12 months fewer alveoli are found within the mammary glands compared to in wild-type mice
increased mammary gland tumor incidence ( J:162126 )
• 7 of 11 mice develop mammary gland tumors with a latency of 9 months unlike wild-type mice
mammary gland hyperplasia ( J:162126 )
• mammary glands exhibit multifocal hyperplasia unlike in wild-type mice that are more uniform than in Chek1tm2.1Sje Trp53tm1Brn Tg(MMTV-cre)Mam heterozygotes




Genotype
MGI:4818615
cn2
Allelic
Composition		 Chek1tm2.1Sje/Chek1tm2.1Sje
Trp53tm1Brn/Trp53tm1Brn
Tg(MMTV-cre)#Mam/0
Genetic
Background		 involves: 129P2/OlaHsd * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chek1tm2.1Sje mutation (0 available); any Chek1 mutation (41 available)
Tg(MMTV-cre)#Mam mutation (0 available)
Trp53tm1Brn mutation (18 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:162126 )
N
• mammary glands do not exhibit hyperplastic foci

neoplasm
abnormal tumor morphology ( J:162126 )
• tumors are more complex than in Trp53tm1Brn Tg(MMTV-cre)Mam homozygotes
decreased tumor incidence ( J:162126 )
• mice develop fewer tumors than in Trp53tm1Brn Tg(MMTV-cre)Mam homozygotes

endocrine/exocrine glands
abnormal mammary gland alveolus morphology ( J:162126 )
• at 12 months fewer alveoli are found within the mammary glands compared to in wild-type mice

integument
abnormal mammary gland alveolus morphology ( J:162126 )
• at 12 months fewer alveoli are found within the mammary glands compared to in wild-type mice




Genotype
MGI:4818618
cn3
Allelic
Composition		 Chek1tm2.1Sje/Chek1tm2.1Sje
Trp53tm1Brn/Trp53+
Tg(MMTV-cre)#Mam/0
Genetic
Background		 involves: 129P2/OlaHsd * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chek1tm2.1Sje mutation (0 available); any Chek1 mutation (41 available)
Tg(MMTV-cre)#Mam mutation (0 available)
Trp53tm1Brn mutation (18 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary gland tumor incidence ( J:162126 )
• 3 of 21 mice develop mammary gland tumors with a latency of 21 months unlike wild-type mice

endocrine/exocrine glands
abnormal mammary gland alveolus morphology ( J:162126 )
• at 12 months fewer alveoli are found within the mammary glands compared to in wild-type mice
increased mammary gland tumor incidence ( J:162126 )
• 3 of 21 mice develop mammary gland tumors with a latency of 21 months unlike wild-type mice

integument
abnormal mammary gland alveolus morphology ( J:162126 )
• at 12 months fewer alveoli are found within the mammary glands compared to in wild-type mice
increased mammary gland tumor incidence ( J:162126 )
• 3 of 21 mice develop mammary gland tumors with a latency of 21 months unlike wild-type mice




Genotype
MGI:4818619
cn4
Allelic
Composition		 Chek1tm2.1Sje/Chek1+
Trp53tm1Brn/Trp53+
Tg(MMTV-cre)#Mam/0
Genetic
Background		 involves: 129P2/OlaHsd * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chek1tm2.1Sje mutation (0 available); any Chek1 mutation (41 available)
Tg(MMTV-cre)#Mam mutation (0 available)
Trp53tm1Brn mutation (18 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
abnormal tumor vascularization ( J:162126 )
• extensive with patches of reduced angiogenesis
increased mammary gland tumor incidence ( J:162126 )
• 20 of 33 mice develop mammary gland tumors with a median latency of 10.5 months unlike wild-type mice
abnormal tumor morphology ( J:162126 )
• tumors are more complex than in Trp53tm1Brn Tg(MMTV-cre)Mam homozygotes
• tumors exhibit aneuploidy and chromosomal aberrations

cellular
aneuploidy ( J:162126 )
• in tumors

cardiovascular system
abnormal tumor vascularization ( J:162126 )
• extensive with patches of reduced angiogenesis

endocrine/exocrine glands
abnormal branching of the mammary ductal tree ( J:162126 )
• at 12 months, mammary glands exhibit increased branching morphogenesis and hyperplastic foci compared to in wild-type mice
abnormal mammary gland alveolus morphology ( J:162126 )
• at 12 months fewer alveoli are found within the mammary glands compared to in wild-type mice
increased mammary gland tumor incidence ( J:162126 )
• 20 of 33 mice develop mammary gland tumors with a median latency of 10.5 months unlike wild-type mice
mammary gland hyperplasia ( J:162126 )
• starting at 12 months, mammary glands exhibit hyperplastic and non-invasive focal lesions unlike wild-type mice

integument
abnormal branching of the mammary ductal tree ( J:162126 )
• at 12 months, mammary glands exhibit increased branching morphogenesis and hyperplastic foci compared to in wild-type mice
abnormal mammary gland alveolus morphology ( J:162126 )
• at 12 months fewer alveoli are found within the mammary glands compared to in wild-type mice
increased mammary gland tumor incidence ( J:162126 )
• 20 of 33 mice develop mammary gland tumors with a median latency of 10.5 months unlike wild-type mice
mammary gland hyperplasia ( J:162126 )
• starting at 12 months, mammary glands exhibit hyperplastic and non-invasive focal lesions unlike wild-type mice




Genotype
MGI:4818608
cn5
Allelic
Composition		 Chek1tm2.1Sje/Chek1+
Tg(MMTV-cre)#Mam/0
Genetic
Background		 involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chek1tm2.1Sje mutation (0 available); any Chek1 mutation (41 available)
Tg(MMTV-cre)#Mam mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:162126 )
N
• mice do not develop mammary gland tumors

endocrine/exocrine glands
abnormal mammary gland morphology ( J:162126 )
• at 2 to 12 months, mammary glands are less dense than in wild-type mice
abnormal mammary gland alveolus morphology ( J:162126 )
• at 12 months fewer alveoli are found within the mammary glands compared to in wild-type mice

integument
abnormal mammary gland morphology ( J:162126 )
• at 2 to 12 months, mammary glands are less dense than in wild-type mice
abnormal mammary gland alveolus morphology ( J:162126 )
• at 12 months fewer alveoli are found within the mammary glands compared to in wild-type mice




Genotype
MGI:4818609
cn6
Allelic
Composition		 Chek1tm2.1Sje/Chek1tm2.1Sje
Tg(MMTV-cre)#Mam/0
Genetic
Background		 involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chek1tm2.1Sje mutation (0 available); any Chek1 mutation (41 available)
Tg(MMTV-cre)#Mam mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:162126 )
N
• mice do not develop mammary gland tumors

endocrine/exocrine glands
abnormal mammary gland morphology ( J:162126 )
• at 2 to 12 months, mammary glands are less dense than in wild-type mice
abnormal mammary gland alveolus morphology ( J:162126 )
• at 12 months fewer alveoli are found within the mammary glands compared to in wild-type mice

integument
abnormal mammary gland morphology ( J:162126 )
• at 2 to 12 months, mammary glands are less dense than in wild-type mice
abnormal mammary gland alveolus morphology ( J:162126 )
• at 12 months fewer alveoli are found within the mammary glands compared to in wild-type mice




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory