Frs2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Frs2
fibroblast growth factor receptor substrate 2
MGI:1100860

28 phenotypes from 6 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Frs2^tm1.1Fwan/Frs2^tm1.1Fwan involves: C57BL/6	embryonic lethality during organogenesis, complete penetrance	J:128712
Frs2^{tm1b(EUCOMM)Wtsi}/Frs2⁺ C57BL/6N-Frs2^{tm1b(EUCOMM)Wtsi}/H	abnormal auditory brainstem response	J:211773
Frs2^{tm1b(EUCOMM)Wtsi}/Frs2^{tm1b(EUCOMM)Wtsi} C57BL/6N-Frs2^{tm1b(EUCOMM)Wtsi}/H	preweaning lethality, complete penetrance	J:211773
Frs2^tm1Fwan/Frs2^tm1Fwan Nkx2-5^tm1(cre)Rjs/? involves: 129S7/SvEvBrd * C57BL/6	abnormal interventricular septum morphology	J:128712
Frs2^tm1Schl/Frs2^tm1Schl involves: 129S2/SvPas * Swiss Webster	abnormal cerebellar plate morphology	J:102930
	abnormal cerebellum development	J:102930
	abnormal cerebral cortex morphology	J:102930
	abnormal embryonic/fetal subventricular zone morphology	J:102930
	abnormal heart morphology	J:94724
	abnormal limb morphology	J:94724
	abnormal pharyngeal arch morphology	J:94724
	anophthalmia	J:94724
	decreased brain size	J:102930
	microcephaly	J:102930
	microphthalmia	J:94724
	prenatal lethality, complete penetrance	J:94724, J:102930
	thin cerebral cortex	J:102930
	normal vision/eye phenotype	J:94724
Frs2^tm1Schl/Frs2^tm1Schl involves: 129S/SvEv	prenatal lethality, complete penetrance	J:94724
Frs2^tm2Schl/Frs2^tm2Schl involves: 129S2/SvPas	normal craniofacial phenotype	J:102930
	decreased fetal size	J:94724
	normal nervous system phenotype	J:102930
	normal vision/eye phenotype	J:94724
Frs2^tm3Scl/Frs2^tm3Scl either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Swiss Webster)	abnormal primitive streak elongation	J:98883
	abnormal rostral-caudal axis patterning	J:98883
	abnormal trophoblast giant cell morphology	J:98883
	abnormal visceral endoderm morphology	J:98883
	decreased embryo size	J:98883
	embryonic growth retardation	J:98883
	embryonic lethality between implantation and somite formation, complete penetrance	J:98883, J:98901

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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