Frs2^tm1.1Fwan
Targeted Allele Detail

Summary

• Symbol: Frs2^tm1.1Fwan
• Name: fibroblast growth factor receptor substrate 2; targeted mutation 1.1, Fen Wang
• MGI ID: MGI:3768913
• Synonyms: Frs2alpha^nullneo
• Gene: Frs2 Location: Chr10:116905332-116984439 bp, - strand Genetic Position: Chr10, 65.09 cM
• Alliance: Frs2^tm1.1Fwan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:128712
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Frs2^tm1Fwan mice were crossed with Cre knockin mice to generate a null allele in the germline. A truncated gene transcript was confirmed by RNAse protection assay on heterozygote kidney extracts. Heterozygotes were indistinguishabe from wild-type mice, suggesting that the truncated transcript did not encode for a dominant-negative protein. (J:128712)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Frs2 Mutation: 64 strains or lines available

References

• Original: J:128712 Lin Y, et al., Generation of an Frs2alpha conditional null allele. Genesis. 2007 Sep;45(9):554-9
• All: 2 reference(s)