62 phenotypes from 8 alleles in 14 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ltftm1(icre)Tdku/Ltf+ Smad1tm2Rob/Smad1tm2Rob involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6	normal reproductive system phenotype	J:324161
Meox2tm1(cre)Sor/Meox2+ Smad1tm2Rob/Smad1tm2Sor involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6	abnormal stomach epithelium morphology	J:90769
	abnormal stomach morphology	J:90769
	abnormal stomach muscularis externa morphology	J:90769
	meteorism	J:90769
	perinatal lethality, incomplete penetrance	J:90769
Smad1tm1Abr/Smad1tm1.1Abr Tg(Col1a1-cre)1Kry/0 involves: BALB/cJ * C57 * FVB	abnormal skeleton development	J:172689
	abnormal trabecular bone morphology	J:172689
	decreased bone trabecula number	J:172689
	decreased osteoblast cell number	J:172689
	decreased osteoblast proliferation	J:172689
	decreased trabecular bone connectivity density	J:172689
	decreased trabecular bone thickness	J:172689
	decreased trabecular bone volume	J:172689
	impaired osteoblast differentiation	J:172689
	increased bone trabecular spacing	J:172689
Smad1tm1Abr/Smad1tm1.1Abr Tg(Col2a1-cre)1Bhr/0 involves: BALB/cJ * C57 * C57BL/6 * SJL	abnormal neurocranium morphology	J:172689
	delayed bone ossification	J:172689
Smad1tm1Abr/Smad1tm1Abr B.129S-Smad1tm1Abr	no abnormal phenotype detected	J:172689
Smad1tm1Abr/Smad1tm1Abr involves: 129S/SvEv	normal mortality/aging	J:75139
Smad1tm1Rjle/Smad1+ involves: 129S6/SvEvTac * C57BL/6	normal cardiovascular system phenotype	J:224752
Smad1tm1Rjle/Smad1+ involves: 129S6/SvEvTac * NIH Black Swiss	abnormal cranial nerve morphology	J:99098
	abnormal hindbrain morphology	J:99098
	abnormal midbrain morphology	J:99098
	abnormal neural tube morphology	J:99098
	abnormal spinal nerve morphology	J:99098
	postnatal lethality	J:99098
Smad1tm1Rjle/Smad1tm1Rjle either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss)	abnormal allantois morphology	J:73279
	embryonic lethality during organogenesis, complete penetrance	J:73279
	failure of chorioallantoic fusion	J:73279
Smad1tm1Rob/Smad1tm1Rob involves: 129S/SvEv * MF1	abnormal allantois morphology	J:71998
	abnormal chorioallantoic fusion	J:71998
	abnormal chorion morphology	J:71998
	abnormal embryo development	J:71998
	abnormal embryonic epiblast morphology	J:71998
	abnormal extraembryonic tissue morphology	J:71998
	abnormal mesoderm development	J:71998
	abnormal placenta morphology	J:71998
	abnormal ventral body wall morphology	J:71998
	abnormal visceral endoderm morphology	J:71998
	absent umbilical cord	J:71998
	decreased embryo size	J:71998
	decreased primordial germ cell number	J:71998
	disorganized embryonic tissue	J:71998
	distended pericardium	J:71998
	embryonic lethality during organogenesis, complete penetrance	J:71998
	incomplete embryo turning	J:71998
Smad1tm1Sor/Smad1tm1Sor 129S4/SvJaeSor-Smad1tm1Sor	abnormal allantois morphology	J:90769
	abnormal embryo turning	J:90769
	abnormal extraembryonic tissue morphology	J:90769
	abnormal pharyngeal arch morphology	J:90769
	abnormal rostral-caudal axis patterning	J:90769
	absent primordial germ cells	J:90769
	caudal body truncation	J:90769
	embryonic lethality during organogenesis, complete penetrance	J:90769
	enlarged pericardium	J:90769
Smad1tm1Sor/Smad1tm1Sor involves: 129S4/SvJaeSor * C57BL/6	abnormal allantois morphology	J:90769
	abnormal embryo turning	J:90769
	abnormal extraembryonic ectoderm morphology	J:90769
	abnormal pharyngeal arch morphology	J:90769
	absent primordial germ cells	J:90769
	caudal body truncation	J:90769
	embryonic lethality during organogenesis, complete penetrance	J:90769
	enlarged pericardium	J:90769
	rostral body truncation	J:90769
Smad1tm1Sor/Smad1tm2Sor involves: 129S4/SvJaeSor * C57BL/6	decreased primordial germ cell number	J:90769
Smad1tm1Tako/Smad1tm1Tako involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * DBA/2	abnormal mesenchyme morphology	J:79513
	absent primordial germ cells	J:79513
	decreased primordial germ cell number	J:79513
	delayed allantois development	J:79513
	embryonic lethality during organogenesis, complete penetrance	J:79513
Smad1tm2Sor/Smad1tm2Sor 129S4/SvJaeSor-Smad1tm2Sor	abnormal cell morphology	J:90769
	abnormal gastric parietal cell morphology	J:90769
	abnormal stomach morphology	J:90769
	absent primordial germ cells	J:90769
Smad1tm2Sor/Smad1tm2Sor involves: 129S4/SvJaeSor * C57BL/6	abnormal cell morphology	J:90769
	abnormal gastric chief cell morphology	J:90769
	abnormal gastric parietal cell morphology	J:90769
	abnormal male reproductive system morphology	J:90769
	absent primordial germ cells	J:90769
	disorganized testis cords	J:90769
	reduced fertility	J:90769
	small testis	J:90769