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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Htr2b
5-hydroxytryptamine (serotonin) receptor 2B
MGI:109323
37 phenotypes from 5 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Htr2btm1b(EUCOMM)Wtsi/Htr2b+
C57BL/6N-Htr2btm1b(EUCOMM)Wtsi/Nju
increased total body fat amount J:211773
Htr2btm1b(EUCOMM)Wtsi/Htr2btm1b(EUCOMM)Wtsi
C57BL/6N-Htr2btm1b(EUCOMM)Wtsi/Nju
preweaning lethality, complete penetrance J:211773
Htr2btm1Dgen/Htr2b+
involves: 129P2/OlaHsd * C57BL/6
no abnormal phenotype detected J:101679
Htr2btm1Dgen/Htr2btm1Dgen
involves: 129P2/OlaHsd * C57BL/6
embryonic lethality, complete penetrance J:101679
Htr2btm1Kry/Htr2btm1Kry
Tg(Col1a1-cre)1Kry/0
involves: FVB
normal skeleton phenotype J:146078
Htr2btm1Lum/Htr2btm1Lum
129S2/SvPas-Htr2btm1Lum
abnormal cardiovascular system morphology J:64067
abnormal cardiovascular system physiology J:79276
abnormal fetal cardiomyocyte proliferation J:64067
abnormal heart development J:64067
abnormal heart ventricle morphology J:64067, J:79276
absent trabeculae carneae J:64067
normal cardiovascular system phenotype J:79276
decreased body weight J:64067
decreased embryo size J:64067
decreased heart weight J:64067
decreased right ventricle systolic pressure J:79276
dilated heart atrium J:64067
disorganized myocardium J:64067
embryonic growth retardation J:64067
embryonic lethality during organogenesis, incomplete penetrance J:64067
postnatal lethality, incomplete penetrance J:64067
reduced fertility J:64067
Tg(Myh6-Htr2b)1Lum/0
involves: CD-1
abnormal heart echocardiography feature J:128784
abnormal heart morphology J:128784
abnormal mitochondrial shape J:128784
abnormal mitochondrion morphology J:128784
abnormal myocardial fiber morphology J:128784
abnormal oxidative phosphorylation J:128784
abnormal respiratory electron transport chain J:128784
cardiac hypertrophy J:128784
enlarged myocardial fiber J:128784
increased heart rate J:128784
increased left ventricle weight J:128784
increased mitochondria number J:128784
increased mitochondrial fission J:128784
increased myocardial fiber number J:128784
thick ventricular wall J:128784

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory