Htr2b Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Htr2b
5-hydroxytryptamine (serotonin) receptor 2B
MGI:109323

40 phenotypes from 5 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Htr2b^{tm1b(EUCOMM)Wtsi}/Htr2b⁺ C57BL/6N-Htr2b^{tm1b(EUCOMM)Wtsi}/Nju	decreased lean body mass	J:211773
	increased total body fat amount	J:211773
Htr2b^tm1Dgen/Htr2b⁺ involves: 129P2/OlaHsd * C57BL/6	no abnormal phenotype detected	J:101679
Htr2b^tm1Dgen/Htr2b^tm1Dgen involves: 129P2/OlaHsd * C57BL/6	embryonic lethality, complete penetrance	J:101679
Htr2b^tm1Kry/Htr2b^tm1Kry Tg(Col1a1-cre)1Kry/0 involves: FVB	normal skeleton phenotype	J:146078
Htr2b^tm1Kry/Htr2b^tm1Kry Tg(Ins2-cre)23Herr/0 involves: C57BL/6J * CBA/J	decreased circulating insulin level	J:284574
	decreased pancreatic beta cell mass	J:284574
	decreased pancreatic beta cell proliferation	J:284574
Htr2b^tm1Lum/Htr2b^tm1Lum 129S2/SvPas-Htr2b^tm1Lum	abnormal cardiovascular system morphology	J:64067
	abnormal cardiovascular system physiology	J:79276
	abnormal fetal cardiomyocyte proliferation	J:64067
	abnormal heart development	J:64067
	abnormal heart ventricle morphology	J:64067, J:79276
	absent trabeculae carneae	J:64067
	normal cardiovascular system phenotype	J:79276
	decreased body weight	J:64067
	decreased embryo size	J:64067
	decreased heart weight	J:64067
	decreased right ventricle systolic pressure	J:79276
	dilated heart atrium	J:64067
	disorganized myocardium	J:64067
	embryonic growth retardation	J:64067
	embryonic lethality during organogenesis, incomplete penetrance	J:64067
	postnatal lethality, incomplete penetrance	J:64067
	reduced fertility	J:64067
Tg(Myh6-Htr2b)1Lum/0 involves: CD-1	abnormal heart echocardiography feature	J:128784
	abnormal heart morphology	J:128784
	abnormal mitochondrial morphology	J:128784
	abnormal mitochondrial shape	J:128784
	abnormal myocardial fiber morphology	J:128784
	abnormal oxidative phosphorylation	J:128784
	abnormal respiratory electron transport chain	J:128784
	cardiac hypertrophy	J:128784
	increased heart left ventricle weight	J:128784
	increased heart rate	J:128784
	increased mitochondrial fission	J:128784
	increased mitochondrial number	J:128784
	increased myocardial fiber number	J:128784
	increased myocardial fiber size	J:128784
	thick ventricular wall	J:128784

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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