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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Il18
interleukin 18
MGI:107936
20 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background
Annotated Term Reference
Ifngtm1Ts/Ifngtm1Ts
Tg(SFTPC-Il18)AThos/0
involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6N * DBA/2
abnormal lung volume J:147547
abnormal pulmonary alveolus morphology J:147547
emphysema J:147547
lung inflammation J:147547
Il12btm1Jm/Il12btm1Jm
Il18tm1Aki/Il18tm1Aki
involves: 129P2/OlaHsd * 129S1/SvImJ
abnormal T-helper 1 physiology J:46514
decreased interferon-gamma secretion J:46514
impaired natural killer cell mediated cytotoxicity J:46514
Il13tm2Anjm/Il13tm2Anjm
Tg(SFTPC-Il18)AThos/0
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * DBA/2
abnormal pulmonary alveolus morphology J:147547
decreased skeletal muscle weight J:219136
normal skeleton phenotype J:219136
weight loss J:219136
Il18tm1Aki/Il18tm1Aki
Il1btm1Dch/Il1btm1Dch
involves: 129P2/OlaHsd * 129S2/SvPas
increased susceptibility to bacterial infection J:112400
Il18tm1Aki/Il18tm1Aki
Nlrp1aNeut1/Nlrp1aNeut1
involves: 129P2/OlaHsd * C57BL/6
abnormal inflammatory response J:191055
increased neutrophil cell number J:191055
myocarditis J:191055
premature death J:191055
Il18tm1Aki/Il18tm1Aki
Tg(KRT14-CASP1)1Miz/0
involves: 129P2/OlaHsd * C57BL/6
decreased IgE level J:78602
decreased IgG1 level J:78602
normal immune system phenotype J:78602
normal integument phenotype J:78602
Il18tm1Khe/Il18tm1Khe
Krt1tm1Tmm/Krt1tm1Tmm
involves: 129P2/OlaHsd * C57BL/6
normal integument phenotype J:200244
normal mortality/aging J:200244

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory