Bcl6 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Bcl6
B cell leukemia/lymphoma 6
MGI:107187

20 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Aicda^tm1Hon/Aicda^tm1Hon Bcl6^tm1.1Jwan/Bcl6^tm1.1Jwan involves: 129S6/SvEvTac * C57BL/6NCrlj * CBA/JNCrlj	abnormal somatic hypermutation frequency	J:190534
Bcl6^tm1.1Jwan/Bcl6^tm1.1Jwan involves: 129S6/SvEvTac	abnormal somatic hypermutation frequency	J:190534
Bcl6^tm1.1Jwan/Bcl6^tm1.1Jwan involves: 129S6/SvEvTac	normal immune system phenotype	J:190534
Bcl6^tm1.1Meln/Bcl6^tm1.1Meln involves: 129 * C57BL/6 * FVB/N	abnormal adaptive immunity	J:194821
	abnormal germinal center B cell physiology	J:194821
	abnormal immune system organ morphology	J:194821
	abnormal Peyer's patch germinal center morphology	J:194821
	abnormal professional antigen presenting cell physiology	J:194821
	abnormal spleen germinal center morphology	J:194821
	decreased IgG1 level	J:194821
	decreased IgG2a level	J:194821
	decreased IgG level	J:194821
	decreased spleen germinal center number	J:194821
	decreased T follicular helper cell number	J:194821
	normal growth/size/body region phenotype	J:194821
	normal immune system phenotype	J:194821
	normal mortality/aging	J:194821
Bcl6^tm1.1Toka/Bcl6⁺ Tg(TcraTcrb)425Cbn/0 involves: BALB/c * C57BL/6 * NZB	decreased T cell proliferation	J:174014
Bcl6^tm1.1Toka/Bcl6^tm1.1Toka Tg(IghelMD4)4Ccg/0 involves: C57BL/6 * NZB	abnormal germinal center B cell physiology	J:174014
	increased activation-induced B cell apoptosis	J:174014
Bcl6^tm1Sdt/Bcl6^tm1Sdt Bcl6b^tm2Dent/Bcl6b^tm2Dent involves: 129/Sv * C57BL/6	abnormal immune system physiology	J:123621
	postnatal growth retardation	J:123621
Bcl6^tm2Rdf/Bcl6^tm2Rdf Ighm^tm1(Bcl6)Rdf/? involves: 129/Sv * 129S1/Sv * C57BL/6	abnormal immune system morphology	J:98937
	abnormal spleen germinal center morphology	J:98937

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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