Pon3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pon3
paraoxonase 3
MGI:106686

41 phenotypes from 4 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pon3^{tm1b(KOMP)Wtsi}/Pon3^{tm1b(KOMP)Wtsi} C57BL/6N-Pon3^{tm1b(KOMP)Wtsi}/Kmpc	increased circulating triglyceride level	J:211773
Pon3^tm1Dmsh/Pon3^tm1Dmsh B6J.129X1-Pon3^tm1Dmsh	abnormal bile composition	J:234615
	abnormal bile salt homeostasis	J:234615
	abnormal lipid level	J:234615
	abnormal mitochondrial ATP synthesis coupled electron transport	J:234615
	abnormal protein level	J:234615
	decreased bile salt level	J:234615
	decreased circulating free fatty acids level	J:234615
	decreased circulating HDL cholesterol level	J:234615
	decreased circulating triglyceride level	J:234615
	decreased fatty acid oxidation	J:234615
	decreased liver triglyceride level	J:234615
	decreased oxygen consumption	J:234615
	gallstones	J:234615
	increased bile salt level	J:234615
	increased body weight	J:234615
	increased circulating alanine transaminase level	J:234615
	increased circulating aspartate transaminase level	J:234615
	increased circulating bilirubin level	J:234615
	increased circulating cholesterol level	J:234615
	increased circulating LDL cholesterol level	J:234615
	increased circulating triglyceride level	J:234615
	increased gonadal fat pad weight	J:234615
	increased hepatocyte apoptosis	J:234615
	increased liver cholesterol level	J:234615
	increased retroperitoneal fat pad weight	J:234615
	increased subcutaneous adipose tissue amount	J:234615
	increased susceptibility to atherosclerosis	J:234615
	increased susceptibility to diet-induced obesity	J:234615
	increased susceptibility to induced morbidity/mortality	J:234615
	increased white fat cell lipid droplet size	J:234615
	increased white fat cell size	J:234615
	jaundice	J:234615
	liver inflammation	J:234615
	normal mortality/aging	J:234615
	oxidative stress	J:234615
Pon3^tm1Lus/Pon3^tm1Lus involves: 129X1/SvJ	decreased glutathione level	J:204799
Pon3^tm1Lus/Pon3^tm1Lus involves: 129X1/SvJ	oxidative stress	J:204799
Pon3^tm1Tigm/Pon3⁺ Not Specified	decreased fetal weight	J:184656
Pon3^tm1Tigm/Pon3⁺ Not Specified	decreased placenta weight	J:184656
Pon3^tm1Tigm/Pon3^tm1Tigm Not Specified	embryonic lethality during organogenesis, incomplete penetrance	J:184656
	lethality throughout fetal growth and development, incomplete penetrance	J:184656
	postnatal lethality, incomplete penetrance	J:184656

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23