Cyp7a1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cyp7a1
cytochrome P450, family 7, subfamily a, polypeptide 1
MGI:106091

45 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cyp7a1^{tm1b(EUCOMM)Wtsi}/Cyp7a1^{tm1b(EUCOMM)Wtsi} C57BL/6N-Cyp7a1^{tm1b(EUCOMM)Wtsi}/Ieg	abnormal lens morphology	J:211773
	abnormal retina blood vessel morphology	J:211773
	abnormal retina morphology	J:211773
	abnormal retina vasculature morphology	J:211773
	abnormal vitreous body morphology	J:211773
	cataract	J:211773
	decreased blood urea nitrogen level	J:211773
	decreased circulating iron level	J:211773
	decreased circulating serum albumin level	J:211773
	decreased exploration in new environment	J:211773
	increased circulating alkaline phosphatase level	J:211773
	increased circulating bilirubin level	J:211773
	increased circulating cholesterol level	J:211773
	increased circulating HDL cholesterol level	J:211773
	increased circulating unsaturated transferrin level	J:211773
	increased leukocyte cell number	J:211773
	increased startle reflex	J:211773
	persistence of hyaloid vascular system	J:211773
Cyp7a1^tm1Rus/Cyp7a1^tm1Rus involves: 129S7/SvEvBrd * C57BL/6J	abnormal bile composition	J:34870
	abnormal bile salt homeostasis	J:34342
	abnormal bile salt level	J:34870
	abnormal epidermis stratum basale morphology	J:34342
	abnormal epidermis stratum granulosum morphology	J:34342
	abnormal fat-soluble vitamin level	J:34342, J:34870
	abnormal lipid homeostasis	J:34870
	abnormal liver morphology	J:34342
	abnormal liver physiology	J:34342
	abnormal skin condition	J:34342
	abnormal skin morphology	J:34342
	abnormal vision	J:34342
	decreased birth weight	J:34342
	decreased exploration in new environment	J:34342
	decreased intestinal cholesterol absorption	J:114411
	decreased locomotor activity	J:34342
	delayed eyelid opening	J:34342
	dry skin	J:34342
	flaky skin	J:34342
	greasy coat	J:34342
	hyperkeratosis	J:34342
	oily skin	J:34342
	perinatal lethality, incomplete penetrance	J:34342
	postnatal growth retardation	J:34342
	postnatal lethality, incomplete penetrance	J:34342
	steatorrhea	J:34342
	thin dermal layer	J:34342
	thin epidermis stratum spinosum	J:34342

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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