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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Gclm
glutamate-cysteine ligase, modifier subunit
MGI:104995
10 phenotypes from 2 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Gclmtm1Tdal/Gclmtm1Tdal
B6.129-Gclmtm1Tdal
abnormal cingulate gyrus morphology J:197430
abnormal nervous system electrophysiology J:197430
oxidative stress J:197430
Gclmtm1Tdal/Gclmtm1Tdal
involves: 129 * C57BL/6J
decreased circulating cysteine level J:80927
decreased cysteine level J:80927
increased cellular sensitivity to hydrogen peroxide J:80927
Gclmtm1Tjka/Gclm+
B6.129-Gclmtm1Tjka
increased physiological sensitivity to xenobiotic J:125009
Gclmtm1Tjka/Gclmtm1Tjka
B6.129-Gclmtm1Tjka
increased circulating alanine transaminase level J:125009
increased physiological sensitivity to xenobiotic J:125009
increased sensitivity to xenobiotic induced morbidity/mortality J:125009
Gclmtm1Tjka/Gclmtm1Tjka
involves: 129S1/Sv * 129X1/SvJ
increased susceptibility to neuronal excitotoxicity J:129045
oxidative stress J:129045
Gclmtm1Tjka/Gclmtm1Tjka
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
increased susceptibility to neuronal excitotoxicity J:129361
oxidative stress J:129361

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory