Gclm^tm1Tjka
Targeted Allele Detail

Summary

• Symbol: Gclm^tm1Tjka
• Name: glutamate-cysteine ligase, modifier subunit; targeted mutation 1, Terrance J Kavanagh
• MGI ID: MGI:3723647
• Synonyms: Gclm^-, Gclm(-)
• Gene: Gclm Location: Chr3:122039206-122060864 bp, + strand Genetic Position: Chr3, 52.94 cM, cytoband H1-3
• Alliance: Gclm^tm1Tjka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:129361
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced by a promotorless beta-geo cassette. Absence of a protein product was confirmed by western blot using liver and kidney tissue. (J:125009)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Gclm^tm1Tjka

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gclm Mutation: 16 strains or lines available

References

• Original: J:129361 Giordano G, et al., Neurotoxicity of domoic Acid in cerebellar granule neurons in a genetic model of glutathione deficiency. Mol Pharmacol. 2006 Dec;70(6):2116-26
• All: 23 reference(s)