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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
MGI:104556
109 phenotypes from 7 alleles in 14 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Cdkn1atm1(HBsAg)Xya/Cdkn1a+
either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Black Swiss)
hepatic steatosis J:88078
increased hepatocellular carcinoma incidence J:88078
Cdkn1atm1(HBsAg)Xya/Cdkn1atm1(HBsAg)Xya
either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Black Swiss)
hepatic steatosis J:88078
increased hepatocellular carcinoma incidence J:88078
Cdkn1atm1.1(KOMP)Vlcg/Cdkn1atm1.1(KOMP)Vlcg
C57BL/6N-Cdkn1atm1.1(KOMP)Vlcg/Ucd
abnormal epididymis morphology J:211773
abnormal heart morphology J:211773
abnormal lung morphology J:211773
abnormal seminal vesicle morphology J:211773
abnormal spleen morphology J:211773
abnormal testis morphology J:211773
decreased circulating insulin level J:211773
enlarged epididymis J:211773
enlarged heart J:211773
enlarged heart atrium J:211773
enlarged spleen J:211773
small seminal vesicle J:211773
small testis J:211773
Cdkn1atm1Hpw/Cdkn1atm1Hpw
involves: 129X1/SvJ
normal growth/size/body region phenotype J:199432
normal homeostasis/metabolism phenotype J:199432
Cdkn1atm1Led/Cdkn1a+
involves: 129S6/SvEvTac
abnormal auchene hair morphology J:125208
abnormal awl hair morphology J:125208
decreased zigzag hair amount J:125208
Cdkn1atm1Led/Cdkn1atm1Led
involves: 129S6/SvEvTac
abnormal auchene hair morphology J:125208
abnormal awl hair morphology J:125208
abnormal cell cycle checkpoint function J:57882
abnormal chromosome number J:57882
decreased zigzag hair amount J:125208
increased anti-double stranded DNA antibody level J:76041
increased anti-histone antibody level J:76041
increased anti-single stranded DNA antibody level J:76041
increased autoantibody level J:76041
increased fibroblast proliferation J:57882
increased T cell proliferation J:76041
premature death J:76041
Cdkn1atm1Led/Cdkn1atm1Led
involves: 129S6/SvEvTac * NIH Black Swiss
abnormal cell cycle J:28420
Cdkn1atm1Led/Cdkn1atm1Led
NIH.Cg-Cdkn1atm1Led
abnormal tumor incidence J:87536
decreased lymphoma incidence J:87536
Cdkn1atm1Led/Cdkn1atm1Led
Tg(Upk2-cre)6Xrw/0
involves: 129S6/SvEvTac * FVB/N
normal neoplasm J:234236
Cdkn1atm1Tyj/Cdkn1a+
involves: 129S1/SvImJ * 129S2/SvPas * C57BL/6J
increased incidence of tumors by ionizing radiation induction J:83967
increased malignant tumor incidence J:83967
Cdkn1atm1Tyj/Cdkn1atm1Tyj
B6;129S2-Cdkn1atm1Tyj/J
abnormal bone marrow cell morphology/development J:108569
normal cardiovascular system phenotype J:216295
decreased monocyte cell number J:108569
decreased susceptibility to induced arthritis J:108569
normal hearing/vestibular/ear phenotype J:98518
impaired macrophage chemotaxis J:108569
Cdkn1atm1Tyj/Cdkn1atm1Tyj
involves: 129/Sv * 129S2/SvPas * C57BL/6
abnormal cell physiology J:72780
abnormal keratinocyte physiology J:72780
abnormal skin physiology J:72780
delayed cellular replicative senescence J:72780
increased squamous cell carcinoma incidence J:72780
Cdkn1atm1Tyj/Cdkn1atm1Tyj
involves: 129S1/SvImJ * 129S2/SvPas * 129S4/SvJae * 129S6/SvEvTac * C57BL/6
normal cardiovascular system phenotype J:216295
Cdkn1atm1Tyj/Cdkn1atm1Tyj
involves: 129S1/SvImJ * 129S2/SvPas * C57BL/6J
increased incidence of tumors by ionizing radiation induction J:83967
increased malignant tumor incidence J:83967
increased metastatic potential J:83967
Cdkn1atm1Tyj/Cdkn1atm1Tyj
involves: 129S2/SvPas
abnormal DNA replication J:59647
abnormal hematopoietic stem cell physiology J:60945
abnormal junctional epithelium morphology J:102001
abnormal neuronal precursor proliferation J:90479
abnormal prostate gland dorsolateral lobe morphology J:115443
altered response to CNS ischemic injury J:90479
decreased body weight J:102001
decreased physiological sensitivity to xenobiotic J:59647
decreased prostate gland weight J:115443
decreased seminal vesicle weight J:115443
increased body weight J:118516
increased brain weight J:118516
increased brown adipose tissue amount J:118516
increased cell proliferation J:180692
increased cellular sensitivity to ultraviolet irradiation J:85569
increased circulating cholesterol level J:118516
increased hematopoietic stem cell number J:60945
increased inguinal fat pad weight J:118516
increased kidney weight J:118516
increased neuron number J:90479
increased neuronal precursor cell number J:90479
increased parametrial fat pad weight J:118516
increased sensitivity to induced cell death J:85569
increased sensitivity to induced morbidity/mortality J:60945
increased sensitivity to xenobiotic induced morbidity/mortality J:60945
increased white fat cell number J:118516
Cdkn1atm1Tyj/Cdkn1atm1Tyj
involves: 129S2/SvPas * C57BL/6
abnormal CD4-positive, alpha beta T cell morphology J:60292
abnormal self tolerance J:60292
abnormal thymus physiology J:70894
decreased incidence of tumors by ionizing radiation induction J:70894
decreased mortality induced by ionizing radiation J:70894
decreased sensitivity to skin irradiation J:114161
enlarged cervical lymph nodes J:60292
enlarged lymph nodes J:60292
enlarged spleen J:60292
glomerulonephritis J:60292, J:70894
normal immune system phenotype J:60292
increased anti-double stranded DNA antibody level J:60292
increased anti-histone antibody level J:60292
increased anti-nuclear antigen antibody level J:60292
increased B cell derived lymphoma incidence J:70894
increased B cell number J:60292
increased carcinoma incidence J:70894
increased cellular sensitivity to gamma-irradiation J:70894
increased hemangiosarcoma incidence J:70894
increased histiocytic sarcoma incidence J:70894
increased IgG1 level J:60292
increased incidence of tumors by chemical induction J:80271
increased Leydig cell tumor incidence J:70894
increased lung carcinoma incidence J:70894
increased memory T cell number J:60292
increased sebaceous gland adenoma incidence J:70894
increased skin tumor incidence J:70894
increased spleen weight J:60292
increased T cell derived lymphoma incidence J:70894
increased T cell proliferation J:60292
increased tumor incidence J:70894
increased urinary system tumor incidence J:70894
increased urine protein level J:60292
kidney failure J:70894
lymph node hyperplasia J:60292
premature death J:60292, J:70894
spleen hyperplasia J:60292
Cdkn1atm2(HBx)Xya/Cdkn1a+
either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Black Swiss)
hepatic steatosis J:88078
increased hepatocellular carcinoma incidence J:88078
Cdkn1atm2(HBx)Xya/Cdkn1atm2(HBx)Xya
either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Black Swiss)
hepatic steatosis J:88078
increased hepatocellular carcinoma incidence J:88078
Tg(Ttr-Cdkn1a)36Tvd/?
B6.Cg-Tg(Ttr-Cdkn1a)36Tvd
abnormal oval cell morphology J:94077
decreased body size J:94077
decreased hepatocyte proliferation J:94077
hyperglycemia J:94077
premature death J:94077

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory