105 phenotypes from 6 alleles in 14 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cdkn1atm1.1(KOMP)Vlcg/Cdkn1atm1.1(KOMP)Vlcg C57BL/6N-Cdkn1atm1.1(KOMP)Vlcg/Ucd	abnormal epididymis morphology	J:211773
	abnormal heart morphology	J:211773
	abnormal spleen morphology	J:211773
	abnormal testis morphology	J:211773
	decreased body length	J:211773
	enlarged epididymis	J:211773
	enlarged heart	J:211773
	enlarged spleen	J:211773
	small testis	J:211773
Cdkn1atm1Hpw/Cdkn1atm1Hpw involves: 129X1/SvJ	normal growth/size/body region phenotype	J:199432
	normal homeostasis/metabolism phenotype	J:199432
Cdkn1atm1Led/Cdkn1a+ involves: 129S6/SvEvTac	abnormal auchene hair morphology	J:125208
	abnormal awl hair morphology	J:125208
	decreased zigzag hair amount	J:125208
Cdkn1atm1Led/Cdkn1atm1Led involves: 129S6/SvEvTac	abnormal auchene hair morphology	J:125208
	abnormal awl hair morphology	J:125208
	abnormal cell cycle checkpoint function	J:57882
	abnormal chromosome number	J:57882
	decreased zigzag hair amount	J:125208
	increased anti-double stranded DNA antibody level	J:76041
	increased anti-histone antibody level	J:76041
	increased anti-single stranded DNA antibody level	J:76041
	increased autoantibody level	J:76041
	increased fibroblast proliferation	J:57882
	increased T cell proliferation	J:76041
	premature death	J:76041
Cdkn1atm1Led/Cdkn1atm1Led involves: 129S6/SvEvTac * NIH Black Swiss	abnormal cell cycle	J:28420
Cdkn1atm1Led/Cdkn1atm1Led NIH.Cg-Cdkn1atm1Led	abnormal tumor incidence	J:87536
	decreased lymphoma incidence	J:87536
Cdkn1atm1Led/Cdkn1atm1Led Tg(Upk2-cre)6Xrw/0 involves: 129S6/SvEvTac * FVB/N	normal neoplasm	J:234236
Cdkn1atm1Tyj/Cdkn1a+ involves: 129S1/SvImJ * 129S2/SvPas * C57BL/6J	increased incidence of tumors by ionizing radiation induction	J:83967
	increased malignant tumor incidence	J:83967
Cdkn1atm1Tyj/Cdkn1atm1Tyj B6;129S2-Cdkn1atm1Tyj/J	abnormal bone marrow cell morphology/development	J:108569
	normal cardiovascular system phenotype	J:216295
	decreased monocyte cell number	J:108569
	decreased susceptibility to induced arthritis	J:108569
	normal hearing/vestibular/ear phenotype	J:98518
	impaired macrophage chemotaxis	J:108569
Cdkn1atm1Tyj/Cdkn1atm1Tyj involves: 129/Sv * 129S2/SvPas * C57BL/6	abnormal cell physiology	J:72780
	abnormal keratinocyte physiology	J:72780
	abnormal skin physiology	J:72780
	delayed cellular replicative senescence	J:72780
	increased squamous cell carcinoma incidence	J:72780
Cdkn1atm1Tyj/Cdkn1atm1Tyj involves: 129S1/SvImJ * 129S2/SvPas * 129S4/SvJae * 129S6/SvEvTac * C57BL/6	normal cardiovascular system phenotype	J:216295
Cdkn1atm1Tyj/Cdkn1atm1Tyj involves: 129S1/SvImJ * 129S2/SvPas * C57BL/6J	increased incidence of tumors by ionizing radiation induction	J:83967
	increased malignant tumor incidence	J:83967
	increased metastatic potential	J:83967
Cdkn1atm1Tyj/Cdkn1atm1Tyj involves: 129S2/SvPas	abnormal hematopoietic stem cell physiology	J:60945
	abnormal junctional epithelium morphology	J:102001
	abnormal neuronal precursor proliferation	J:90479
	abnormal prostate gland dorsolateral lobe morphology	J:115443
	abnormal response to CNS ischemic injury	J:90479
	decreased body weight	J:102001
	decreased physiological sensitivity to xenobiotic	J:59647
	decreased prostate gland dorsolateral lobe weight	J:115443
	decreased seminal vesicle weight	J:115443
	increased body weight	J:118516
	increased brain weight	J:118516
	increased brown adipose tissue amount	J:118516
	increased cell proliferation	J:180692
	increased cellular sensitivity to ultraviolet irradiation	J:85569
	increased circulating cholesterol level	J:118516
	increased DNA replication	J:59647
	increased hematopoietic stem cell number	J:60945
	increased inguinal fat pad weight	J:118516
	increased kidney weight	J:118516
	increased neuron number	J:90479
	increased neuronal precursor cell number	J:90479
	increased parametrial fat pad weight	J:118516
	increased sensitivity to induced cell death	J:85569
	increased susceptibility to induced morbidity/mortality	J:60945
	increased susceptibility to xenobiotic induced morbidity/mortality	J:60945
	increased white fat cell number	J:118516
Cdkn1atm1Tyj/Cdkn1atm1Tyj involves: 129S2/SvPas * C57BL/6	abnormal CD4-positive, alpha beta T cell morphology	J:60292
	abnormal self tolerance	J:60292
	abnormal thymus physiology	J:70894
	decreased incidence of tumors by ionizing radiation induction	J:70894
	decreased mortality induced by ionizing radiation	J:70894
	decreased sensitivity to skin irradiation	J:114161
	enlarged cervical lymph nodes	J:60292
	enlarged lymph nodes	J:60292
	enlarged spleen	J:60292
	glomerulonephritis	J:60292, J:70894
	normal immune system phenotype	J:60292
	increased anti-double stranded DNA antibody level	J:60292
	increased anti-histone antibody level	J:60292
	increased anti-nuclear antigen antibody level	J:60292
	increased B cell derived lymphoma incidence	J:70894
	increased B cell number	J:60292
	increased carcinoma incidence	J:70894
	increased cellular sensitivity to gamma-irradiation	J:70894
	increased hemangiosarcoma incidence	J:70894
	increased histiocytic sarcoma incidence	J:70894
	increased IgG1 level	J:60292
	increased incidence of tumors by chemical induction	J:80271
	increased Leydig cell tumor incidence	J:70894
	increased lung carcinoma incidence	J:70894
	increased memory T cell number	J:60292
	increased sebaceous gland adenoma incidence	J:70894
	increased skin tumor incidence	J:70894
	increased spleen weight	J:60292
	increased T cell derived lymphoma incidence	J:70894
	increased T cell proliferation	J:60292
	increased tumor incidence	J:70894
	increased urinary system tumor incidence	J:70894
	increased urine protein level	J:60292
	kidney failure	J:70894
	lymph node hyperplasia	J:60292
	premature death	J:60292, J:70894
	spleen hyperplasia	J:60292
Cdkn1atm2(HBx)Xya/Cdkn1a+ either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Black Swiss)	hepatic steatosis	J:88078
	increased hepatocellular carcinoma incidence	J:88078
Cdkn1atm2(HBx)Xya/Cdkn1atm2(HBx)Xya either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Black Swiss)	hepatic steatosis	J:88078
	increased hepatocellular carcinoma incidence	J:88078
Tg(Ttr-Cdkn1a)36Tvd/? B6.Cg-Tg(Ttr-Cdkn1a)36Tvd	abnormal oval cell morphology	J:94077
	decreased body size	J:94077
	decreased hepatocyte proliferation	J:94077
	hyperglycemia	J:94077
	premature death	J:94077