Herc2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Herc2
HECT and RLD domain containing E3 ubiquitin protein ligase 2
MGI:103234

22 phenotypes from 13 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Herc2^{Gt(AR0530)Wtsi}/Herc2⁺ involves: 129P2/OlaHsd * C57BL/6	abnormal autophagy	J:252045
	abnormal lysosome morphology	J:252045
	abnormal Purkinje cell dendrite morphology	J:252045
	impaired coordination	J:252045
	normal nervous system phenotype	J:252045
	Purkinje cell axonal dystrophy	J:252045
	Purkinje cell degeneration	J:252045
Herc2^{Gt(AR0530)Wtsi}/Herc2^{Gt(AR0530)Wtsi} involves: 129P2/OlaHsd * C57BL/6	embryonic lethality, complete penetrance	J:252045
Herc2^J/Herc2^J BALB/cJ-Herc2^J	abnormal spermatid morphology	J:58776
	decreased body size	J:58776
	decreased corpora lutea number	J:58776
	decreased male germ cell number	J:58776
	male infertility	J:58776
	oligozoospermia	J:58776
	reduced female fertility	J:58776
	tremors	J:58776
Herc2^jdf2-1R/Herc2^jdf2-1R Not Specified	abnormal behavior	J:100221
	decreased body size	J:100221
	female infertility	J:100221
	male infertility	J:100221
Herc2^jdf2-2R/Herc2^jdf2-2R Not Specified	abnormal behavior	J:100221
	decreased body size	J:100221
	female infertility	J:100221
	male infertility	J:100221
Herc2^jdf2-3R/Herc2^jdf2-3R Not Specified	abnormal behavior	J:100221
	decreased body size	J:100221
	female infertility	J:100221
	male infertility	J:100221
Herc2^jdf2-4R/Herc2^jdf2-4R Not Specified	prenatal lethality, complete penetrance	J:100221
Herc2^jdf2-5R/Herc2^jdf2-5R Not Specified	prenatal lethality, complete penetrance	J:100221
Herc2^jdf2-6R/Herc2^jdf2-6R Not Specified	prenatal lethality, complete penetrance	J:100221
Herc2^jdf2-7R/Herc2^jdf2-7R Not Specified	prenatal lethality, complete penetrance	J:100221
Herc2^jdf2-8R/Herc2^jdf2-8R Not Specified	abnormal behavior	J:100221
	decreased body size	J:100221
	female infertility	J:100221
	male infertility	J:100221
Herc2^jdf2-9R/Herc2^jdf2-9R Not Specified	decreased body size	J:100221
Herc2^jdf2-9R/Herc2^jdf2-9R Not Specified	postnatal lethality, incomplete penetrance	J:100221
Herc2^jdf2-10R/Herc2^jdf2-10R Not Specified	decreased body size	J:100221
Herc2^jdf2-10R/Herc2^jdf2-10R Not Specified	postnatal lethality, incomplete penetrance	J:100221
Herc2^mpc178H/Herc2^mpc178H involves: BALB/c * C3H/HeH * C57BL/6J	decreased body fat mass	J:234901
	decreased lean body mass	J:234901

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23