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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Grb10
growth factor receptor bound protein 10
MGI:103232
49 phenotypes from 5 alleles in 6 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background
Annotated Term Reference
Grb10Gt(Betageo)1Ward/Grb10+
involves: C57BL/6 * CBA
abnormal pulmonary alveolus morphology J:84425
abnormal trachea morphology J:84425
enlarged liver J:84425
enlarged placenta J:84425
increased birth body size J:84425
increased fetal size J:84425
increased liver glycogen level J:84425
paternal imprinting J:84425
perinatal lethality, incomplete penetrance J:84425
Grb10Gt(Betageo)1Ward/Grb10Gt(Betageo)1Ward
involves: C57BL/6 * CBA
enlarged liver J:84425
enlarged placenta J:84425
increased birth body size J:84425
increased fetal size J:84425
Grb10GT(XC302)Byg/Grb10GT(XC302)Byg
involves: 129P2/OlaHsd * Black Swiss * C57BL/6
increased body weight J:125128
increased insulin sensitivity J:125128
increased lean body mass J:125128
increased lung weight J:125128
increased muscle weight J:125128
increased pancreas weight J:125128
Grb10tm1.1Fliu/Grb10tm1.1Fliu
Tg(Adipoq-cre)#Pesch/0
involves: 129S/SvEv * FVB
abnormal adipose tissue physiology J:213603
abnormal brown adipose tissue physiology J:213603
abnormal epididymal fat pad morphology J:213603
abnormal interscapular fat pad morphology J:213603
decreased core body temperature J:213603
decreased fatty acid oxidation J:213603
decreased oxygen consumption J:213603
hepatic steatosis J:213603
impaired adaptive thermogenesis J:213603
impaired glucose tolerance J:213603
increased body fat mass J:213603
increased body weight J:213603
increased brown fat cell size J:213603
increased circulating insulin level J:213603
increased susceptibility to age related obesity J:213603
increased susceptibility to diet-induced obesity J:213603
increased white fat cell size J:213603
insulin resistance J:213603
whitened brown adipose tissue morphology J:213603
Grb10tm1.1Fliu/Grb10tm1.1Fliu
Tg(Fabp4-cre)1Rev/0
involves: 129S/SvEv
abnormal epididymal fat pad morphology J:213603
hepatic steatosis J:213603
impaired glucose tolerance J:213603
increased body fat mass J:213603
increased body weight J:213603
increased brown fat cell size J:213603
increased circulating insulin level J:213603
increased susceptibility to age related obesity J:213603
increased susceptibility to diet-induced obesity J:213603
increased white fat cell size J:213603
insulin resistance J:213603
whitened brown adipose tissue morphology J:213603
Grb10tm1.1Fliu/Grb10tm1.1Fliu
Tg(Pdx1-cre)6Tuv/0
involves: 129S/SvEv * C57BL/6 * FVB/N
abnormal glucose homeostasis J:208498
abnormal pancreatic beta cell morphology J:208498
abnormal pancreatic beta cell physiology J:208498
decreased circulating glucose level J:208498
decreased susceptibility to weight loss J:208498
normal homeostasis/metabolism phenotype J:208498
improved glucose tolerance J:208498
increased insulin secretion J:208498
increased pancreas weight J:208498
increased pancreatic beta cell mass J:208498
increased pancreatic beta cell proliferation J:208498
Grb10tm1.1Fuis/Grb10+
involves: 129S/SvEv * C57BL/6J
decreased body weight J:146865
decreased fetal size J:146865
decreased placenta weight J:146865
embryonic growth retardation J:146865
small placenta J:146865
Grb10tm1Fuis/Grb10+
involves: 129S/SvEv * C57BL/6J
normal growth/size/body region phenotype J:146865

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory