Spr Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Spr
sepiapterin reductase
MGI:103078

24 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Spr^em1(IMPC)H/Spr⁺ C57BL/6N-Spr^em1(IMPC)H/H	increased grip strength	J:211773
	increased hematocrit	J:211773
	increased mean corpuscular volume	J:211773
	increased neutrophil cell number	J:211773
Spr^em1(IMPC)H/Spr^em1(IMPC)H C57BL/6N-Spr^em1(IMPC)H/H	preweaning lethality, complete penetrance	J:211773
Spr^tm1Lex/Spr^tm1Lex involves: 129S/SvEvBrd * C57BL/6J	abnormal biopterin level	J:131376
	abnormal neopterin level	J:131376
	bradykinesia	J:131376
	decreased body weight	J:131376
	decreased dopamine level	J:131376
	decreased locomotor activity	J:131376
	decreased noradrenaline level	J:131376
	decreased phenylalanine level	J:131376
	decreased serotonin level	J:131376
	postnatal growth retardation	J:131376
	premature death	J:131376
	prenatal lethality, incomplete penetrance	J:131376
	tremors	J:131376
Spr^tm1Spo/Spr^tm1Spo involves: 129 * C57BL/6	abnormal biopterin level	J:124817
	abnormal dopaminergic neuron morphology	J:124817
	abnormal enzyme/coenzyme level	J:124817
	abnormal locomotor activation	J:124817
	abnormal neopterin level	J:124817
	abnormal synaptic neurotransmitter level	J:124817
	decreased circulating insulin-like growth factor I level	J:124817
	decreased dopamine level	J:124817
	decreased noradrenaline level	J:124817
	decreased serotonin level	J:124817
	increased circulating phenylalanine level	J:124817
	postnatal growth retardation	J:124817
	premature death	J:124817

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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