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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pdx1
pancreatic and duodenal homeobox 1
MGI:102851
70 phenotypes from 10 alleles in 14 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Pdx1tm1.1Stof/Pdx1+
involves: 129/Sv * C57BL/6 		abnormal pancreatic endocrine progenitor cell physiology J:152582
decreased circulating insulin level J:152582
decreased pancreatic beta cell mass J:152582
impaired glucose tolerance J:152582
pancreas hypoplasia J:152582
Pdx1tm1.1Stof/Pdx1tm1.1Stof
involves: 129/Sv * C57BL/6 		abnormal pancreas development J:152582
abnormal pancreatic delta cell morphology J:152582
abnormal pancreatic epsilon cell morphology J:152582
abnormal PP cell morphology J:152582
decreased circulating insulin level J:152582
decreased pancreatic alpha cell mass J:152582
decreased pancreatic beta cell mass J:152582
normal endocrine/exocrine gland phenotype J:152582
hyperglycemia J:152582
impaired glucose tolerance J:152582
pancreatic islet hypoplasia J:152582
Pdx1tm1b(EUCOMM)Wtsi/Pdx1+
C57BL/6N-Pdx1tm1b(EUCOMM)Wtsi/Bay 		impaired glucose tolerance J:211773
Pdx1tm1b(EUCOMM)Wtsi/Pdx1tm1b(EUCOMM)Wtsi
C57BL/6N-Pdx1tm1b(EUCOMM)Wtsi/Bay 		preweaning lethality, complete penetrance J:211773
Pdx1tm1Cvw/Pdx1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal pancreatic beta cell physiology J:165268
abnormal pancreatic islet size J:165268
decreased insulin secretion J:165268
decreased pancreatic beta cell number J:165268
disorganized pancreatic islets J:165268
normal endocrine/exocrine gland phenotype J:165268
impaired glucose tolerance J:165268
increased circulating glucose level J:165268
increased pancreatic beta cell apoptosis J:165268
small pancreatic islets J:165268
Pdx1tm1Cvw/Pdx1tm1.1Stof
involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6 		decreased pancreas weight J:152582
hyperglycemia J:152582
small pancreas J:152582
Pdx1tm1Cvw/Pdx1tm1Cvw
involves: 129S1/Sv * 129X1/SvJ * Black Swiss 		abnormal bile duct development J:32017
abnormal duodenum morphology J:32017
abnormal foregut morphology J:32017
abnormal liver development J:32017
abnormal pancreatic acinar cell morphology J:32017
abnormal pancreatic beta cell differentiation J:32017
abnormal pancreatic duct morphology J:32017
abnormal pancreatic islet morphology J:32017
abnormal pyloric sphincter morphology J:32017
abnormal small intestine morphology J:32017
abnormal stomach morphology J:32017
absent Brunner's glands J:32017
absent pancreas J:32017
decreased body weight J:32017
dehydration J:32017
postnatal growth retardation J:32017
postnatal lethality, complete penetrance J:32017
sparse hair J:32017
thin skin J:32017
Pdx1tm1Cvw/Pdx1tm4Cvw
Tg(Ins2-cre)25Mgn/0
involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 * DBA 		abnormal pancreas morphology J:130389
decreased circulating insulin level J:130389
decreased pancreatic beta cell number J:130389
decreased pancreatic beta cell proliferation J:130389
disorganized pancreatic islets J:130389
impaired glucose tolerance J:130389
increased circulating glucose level J:130389
increased pancreatic alpha cell number J:130389
increased pancreatic alpha cell proliferation J:130389
increased pancreatic delta cell number J:130389
Pdx1tm1Egs/Pdx1+
involves: 129S1/Sv 		no abnormal phenotype detected J:110137
Pdx1tm1Heed/Pdx1tm1Heed
Tg(Ins2-cre)1Heed/0
involves: 129P2/OlaHsd * C57BL/6 * CBA 		abnormal pancreatic beta cell physiology J:48516
abnormal pancreatic islet morphology J:48516
decreased pancreatic beta cell number J:48516
disorganized pancreatic islets J:48516
increased circulating glucose level J:48516
increased pancreatic alpha cell number J:48516
increased urine glucose level J:48516
Pdx1tm1Macd/Pdx1+
involves: 129S1/Sv * 129X1/SvJ 		impaired glucose tolerance J:79206, J:101742
Pdx1tm1Macd/Pdx1tm1Macd
involves: 129S1/Sv * 129X1/SvJ 		normal liver/biliary system phenotype J:151981
Pdx1tm1Ted/Pdx1+
involves: 129P2/OlaHsd 		abnormal pancreatic beta cell apoptosis J:82969
abnormal pancreatic islet cell apoptosis J:82969
abnormal pancreatic islet morphology J:82969
decreased insulin secretion J:82969
decreased pancreatic beta cell mass J:82969
decreased pancreatic islet number J:82969
impaired glucose tolerance J:48516, J:82969
increased circulating glucose level J:82969
pancreas inflammation J:82969
small pancreatic islets J:82969
Pdx1tm1Ted/Pdx1tm1Ted
involves: 129P2/OlaHsd 		abnormal pancreas development J:33133
abnormal small intestine placement J:20779
absent pancreas J:20779
decreased body size J:20779
normal immune system phenotype J:20779
increased circulating glucose level J:20779
normal liver/biliary system phenotype J:20779
postnatal lethality, complete penetrance J:20779
Pdx1tm2Cvw/Pdx1+
involves: 129/Sv * Black Swiss 		decreased insulin secretion J:97234
impaired glucose tolerance J:97234
Pdx1tm2Cvw/Pdx1+
involves: 129S1/Sv * 129X1/SvJ * Black Swiss 		abnormal mitochondrial physiology J:75664
abnormal pancreatic beta cell physiology J:75664
abnormal tricarboxylic acid cycle J:75664
decreased amylin secretion J:75664
decreased insulin secretion J:75664
normal homeostasis/metabolism phenotype J:75664
impaired glucose tolerance J:75664
increased glucagon secretion J:75664
Pdx1tm2Cvw/Pdx1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA 		impaired glucose tolerance J:104617
Pdx1tm2Cvw/Pdx1tm2Cvw
involves: 129S1/Sv * 129X1/SvJ * Black Swiss 		abnormal bile duct development J:32017
abnormal duodenum morphology J:32017
abnormal foregut morphology J:32017
abnormal liver development J:32017
abnormal pancreatic acinar cell morphology J:32017
abnormal pancreatic beta cell differentiation J:32017
abnormal pancreatic duct morphology J:32017
abnormal pancreatic islet morphology J:32017
abnormal pyloric sphincter morphology J:32017
abnormal small intestine morphology J:32017
abnormal stomach morphology J:32017
absent pancreas J:32017
decreased body weight J:32017
dehydration J:32017
postnatal growth retardation J:32017
postnatal lethality, complete penetrance J:32017
sparse hair J:32017
thin skin J:32017
Pdx1tm2Cvw/Pdx1tm2Cvw
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA 		abnormal intestine morphology J:104617
abnormal stomach enteroendocrine cell morphology J:104617
abnormal stomach pyloric region morphology J:104617
distended stomach J:104617
Pdx1tm2Cvw/Pdx1tm3Cvw
involves: 129/Sv * C57BL/6 * DBA * FVB/N 		abnormal enteroendocrine cell morphology J:104617
abnormal pancreas development J:104617
dehydration J:104617
exocrine pancreatic insufficiency J:104617
postnatal growth retardation J:104617
postnatal lethality, complete penetrance J:104617
Pdx1tm3Cvw/Pdx1+
involves: 129S6/SvEvTac * C57BL/6 * DBA * FVB/N 		decreased circulating insulin level J:104617
disorganized pancreatic islets J:104617
impaired glucose tolerance J:104617
increased circulating glucose level J:104617
increased pancreatic alpha cell number J:104617
increased PP cell number J:104617
Pdx1tm3Cvw/Pdx1tm3Cvw
involves: 129S6/SvEvTac * C57BL/6 * DBA * FVB/N 		abnormal enteroendocrine cell morphology J:104617
abnormal pancreas development J:104617
postnatal lethality, complete penetrance J:104617
Pdx1tm4Cvw/Pdx1tm4Cvw
involves: 129S1/Sv * 129X1/SvJ * Black Swiss 		no abnormal phenotype detected J:130389
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/30/2024
MGI 6.23 		The Jackson Laboratory