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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Tpp2
tripeptidyl peptidase II
MGI:102724
35 phenotypes from 2 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Tpp2Gt(OST432061)Lex/Tpp2Gt(OST432061)Lex
B6.129S5-Tpp2Gt(OST432061)Lex
abnormal level of surface class I molecules J:157195
normal hematopoietic system phenotype J:157195
Tpp2Gt(OST432061)Lex/Tpp2Gt(OST432061)Lex
involves: 129S5/SvEvBrd * C57BL/6
abnormal antigen presentation J:157195
Tpp2tm1.1Gnie/Tpp2tm1.1Gnie
involves: 129S6/SvEvTac
abnormal CD4-positive T cell differentiation J:221205
abnormal CD8-positive, alpha-beta T cell differentiation J:221205
abnormal lymphocyte physiology J:221205
decreased leukocyte cell number J:221205
enlarged lymph nodes J:221205
enlarged spleen J:221205
increased anti-nuclear antigen antibody level J:221205
increased autoantibody level J:221205
increased B cell number J:221205
increased memory T cell number J:221205
Tpp2tm1.1Gnie/Tpp2tm1.1Gnie
involves: 129S6/SvEvTac * C57BL/6
abnormal cell cycle J:133572
abnormal cytotoxic T cell physiology J:133572
abnormal immune system cell morphology J:133572
abnormal immune system organ morphology J:133572
abnormal spleen morphology J:133572
abnormal splenic cell ratio J:133572
decreased CD8-positive, alpha-beta T cell number J:133572
decreased double-positive T cell number J:133572
decreased T cell number J:133572
disheveled coat J:133572
early cellular replicative senescence J:133572
enlarged spleen J:133572
extramedullary hematopoiesis J:133572
focal hair loss J:133572
increased double-negative T cell number J:133572
increased single-positive T cell number J:133572
increased spleen red pulp amount J:133572
increased T cell apoptosis J:133572
increased T cell number J:133572
premature aging J:133572
premature death J:133572
thymus atrophy J:133572
weight loss J:133572

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/31/2018
MGI 6.12
The Jackson Laboratory