Tpp2^tm1.1Gnie
Targeted Allele Detail

Summary

• Symbol: Tpp2^tm1.1Gnie
• Name: tripeptidyl peptidase II; targeted mutation 1.1, Gabriele Niedermann
• MGI ID: MGI:3783750
• Synonyms: TPPII KO
• Gene: Tpp2 Location: Chr1:43973130-44042160 bp, + strand Genetic Position: Chr1, 23.5 cM
• Alliance: Tpp2^tm1.1Gnie page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:133572
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 11 and 12 were removed by germ-line, cre-mediated recombination. The absence of protein activity was confirmed by an alanyl-alanyl-phenylalanyl-7-amino-4-methylcoumarin-degradation assay on splenocyte lysates and the absence of protein product was confirmed by western blot analysis on peripheral blood cell extracts. (J:133572)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tpp2 Mutation: 80 strains or lines available

Notes

Phenotypic Similarity to Human Syndrome: Evans Syndrome J:221205.

References

• Original: J:133572 Huai J, et al., Activation of cellular death programs associated with immunosenescence-like phenotype in TPPII knockout mice. Proc Natl Acad Sci U S A. 2008 Apr 1;105(13):5177-82
• All: 4 reference(s)