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Scarb2 Gene Detail
Summary
  • Symbol
    Scarb2
  • Name
    scavenger receptor class B, member 2
  • Synonyms
    9330185J12Rik, Cd36l2, LGP85, LIMP-2, LIMP II
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196458
    NCBI Gene: 12492
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:92589170-92653516 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 46.82 cM, cytoband E3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    476 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196458
 protein coding gene Chr5:92589170-92654692 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029752
 protein coding gene Chr5:93640628-93704815 (-)
A/J MGP_AJ_G0029718
 protein coding gene Chr5:89922115-89981769 (-)
AKR/J MGP_AKRJ_G0029664
 protein coding gene Chr5:92857504-92923589 (-)
BALB/cJ MGP_BALBcJ_G0029728
 protein coding gene Chr5:90795073-90855755 (-)
C3H/HeJ MGP_C3HHeJ_G0029451
 protein coding gene Chr5:93260101-93321222 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030182
 protein coding gene Chr5:97346305-97416330 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027418
 protein coding gene Chr5:85559982-85621283 (-)
CAST/EiJ MGP_CASTEiJ_G0028861
 protein coding gene Chr5:92638047-92701871 (-)
CBA/J MGP_CBAJ_G0029421
 protein coding gene Chr5:100742040-100818043 (-)
DBA/2J MGP_DBA2J_G0029565
 protein coding gene Chr5:89960754-90023428 (-)
FVB/NJ MGP_FVBNJ_G0029524
 protein coding gene Chr5:88804939-88866302 (-)
LP/J MGP_LPJ_G0029653
 protein coding gene Chr5:94001264-94064910 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029553
 protein coding gene Chr5:105634230-105709675 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030216
 protein coding gene Chr5:92380914-92448968 (-)
PWK/PhJ MGP_PWKPhJ_G0028580
 protein coding gene Chr5:89027090-89088643 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028415
 protein coding gene Chr5:91747506-91809703 (-)
WSB/EiJ MGP_WSBEiJ_G0028940
 protein coding gene Chr5:92852196-92920127 (-)



Homology
more
  • Human Ortholog
    SCARB2, scavenger receptor class B member 2
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SCARB2, scavenger receptor class B member 2
  • Synonyms
    AMRF, CD36L2, EPM4, HLGP85, LGP85, LIMP-2, LIMPII, SR-BII
  • Links
    NCBI Gene ID: 950
    neXtProt AC: NX_Q14108
    UniProt: Q14108

  • Chr Location
    4q21.1; chr4:76158737-76234536 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Scarb2 mouse models; 1 with human SCARB2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    65 phenotypes from 2 alleles in 3 genetic backgrounds
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in renal dysfunction, progressive deafness, and progressive demylination of the peripheral nerves. Mutant animals show a 2-fold increased water consumption along with increased urine volume, and develop an enlarged, ball-like trunk with age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    747
  • Tissues
    30
  • cDNA Data
    18
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12492 NCBI Gene Model | MGI Sequence Detail 64347 C57BL/6J ±  kb
    transcript NM_007644 RefSeq | MGI Sequence Detail 4729 C57BL/6  
    polypeptide O35114 UniProt | EBI | MGI Sequence Detail 478 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 19

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2445131
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 8
      Phenotypes 33
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:330183 Zou Y, et al., The Deficiency of SCARB2/LIMP-2 Impairs Metabolism via Disrupted mTORC1-Dependent Mitochondrial OXPHOS. Int J Mol Sci. 2022 Aug 3;23(15)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory