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Tff3
Gene Detail
 Symbol
Name
ID
Tff3
trefoil factor 3, intestinal
MGI:104638
Synonyms ITF, mITF
Feature Type protein coding gene
Genetic Map
Chromosome 17
15.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr17:31125306-31129646 bp, - strand
From VEGA annotation of GRCm38

  4341 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2427  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: trefoil factor, types 1 and 3
Gene Tree: Tff3

Human
homologs
Human Homolog TFF3, trefoil factor 3 (intestinal)
NCBI Gene ID 7033
neXtProt AC  NX_Q07654
Human Synonyms  ITF, P1B, TFI
Human Chr (Location)  21q22.3; chr21:42311667-42315596 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(4) Targeted(6)
Genomic Mutations involving Tff3 (4)
 
Homozygous mutation of this gene results in impaired intestinal mucosal healing and death from colitis after administration of dextran sulfate sodium. Mice show poor epithelial regeneration after injury.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Tff3 interacts with 21 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (4 annotations)
Component extracellular region, extracellular vesicular exosome, ...
External Resources: FuncBase
Expression
Literature Summary: (24 records)
Data Summary: Results (280)    Tissues (194)    Images (17)
Theiler Stages: 13, 14, 15, 17, 20, 22, 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 216
RT-PCR 64
cDNA source data(82)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(92) Genomic(6) cDNA(82) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000020099 (Evidence)
Ensembl Gene ModelENSMUSG00000024029 (Evidence)
Entrez Gene21786 (Evidence)
UniGene4641
DFCITC1579238
DoTSDT.536614
NIA Mouse Gene IndexU037643
Consensus CDS ProjectCCDS37544.1
International Mouse Knockout Project StatusTff3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020099 VEGA Gene Model | MGI Sequence Detail 4341 C57BL/6J ±  kb
transcript OTTMUST00000047795 VEGA | MGI Sequence Detail 493 Not Applicable 
polypeptide OTTMUSP00000021729 VEGA | MGI Sequence Detail 81 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(85 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000519 P-type trefoil
InterPro IPR017994 P-type trefoil, chordata
InterPro IPR017957 P-type trefoil, conserved site
Protein Ontology PR:000016276 trefoil factor 3
References (Earliest) J:25263 Mashimo H, et al., Structure and expression of murine intestinal trefoil factor: high evolutionary conservation and postnatal expression. Biochem Biophys Res Commun. 1995 May 5;210(1):31-7
(Latest) J:209251 Liu SQ, et al., Trefoil factor 3 as an endocrine neuroprotective factor from the liver in experimental cerebral ischemia/reperfusion injury. PLoS One. 2013;8(10):e77732
All references(72)
Other
accession IDs
MGD-MRK-26075

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory