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Tff3
Gene Detail
Symbol

Name
ID
Tff3
trefoil factor 3, intestinal
MGI:104638
Synonyms
ITF, mITF
Feature Type
protein coding gene
Genetic Map
Chromosome 17
15.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr17:31125306-31129646 bp, - strand
From VEGA annotation of GRCm38

  4341 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2427  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: TFF3
Protein SuperFamily: trefoil factor, types 1 and 3
Gene Tree: Tff3

Human
homologs
TFF3, trefoil factor 3 (intestinal)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 7033
neXtProt AC: NX_Q07654

Human Synonyms: ITF, P1B, TFI

Human Chr (Location): 21q22.3; chr21:42311667-42315596 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(4) Targeted(6)
Genomic Mutations involving Tff3 (4)
 
Homozygous mutation of this gene results in impaired intestinal mucosal healing and death from colitis after administration of dextran sulfate sodium. Mice show poor epithelial regeneration after injury.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Tff3 interacts with 21 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Component cytoplasm, extracellular exosome, ...
External Resources: FuncBase
Expression
Literature Summary: (25 records)
Data Summary: Results (301)    Tissues (205)    Images (17)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 7
RNA in situ 216
RT-PCR 78
cDNA source data(82)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(93) Genomic(6) cDNA(82) Primer pair(4) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000020099 (Evidence)
Ensembl Gene Model ENSMUSG00000024029 (Evidence)
Entrez Gene 21786 (Evidence)
UniGene 4641
DFCI TC1579238
DoTS DT.536614
NIA Mouse Gene Index U037643
Consensus CDS Project CCDS37544.1
International Mouse Phenotyping Consortium Status Tff3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020099 VEGA Gene Model | MGI Sequence Detail 4341 C57BL/6J ±  kb
transcript OTTMUST00000047795 VEGA | MGI Sequence Detail 493 Not Applicable 
polypeptide OTTMUSP00000021729 VEGA | MGI Sequence Detail 81 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(85 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000519 P-type trefoil
InterPro IPR017994 P-type trefoil, chordata
InterPro IPR017957 P-type trefoil, conserved site
Protein Ontology PR:000016276 trefoil factor 3
References
(Earliest) J:25263 Mashimo H, et al., Structure and expression of murine intestinal trefoil factor: high evolutionary conservation and postnatal expression. Biochem Biophys Res Commun. 1995 May 5;210(1):31-7
(Latest) J:212415 Kinzel B, et al., Functional roles of Lgr4 and Lgr5 in embryonic gut, kidney and skin development in mice. Dev Biol. 2014 Jun 15;390(2):181-90
All references(72)
Other
accession IDs
MGD-MRK-26075

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory