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Timd4 Gene Detail
Summary
  • Symbol
    Timd4
  • Name
    T cell immunoglobulin and mucin domain containing 4
  • Synonyms
    B430010N18Rik, Tim4, TIM-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2445125
    NCBI Gene: 276891
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:46701627-46735159 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 28.09 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    227 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2445125
 protein coding gene Chr11:46701613-46735160 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018201
 protein coding gene Chr11:45762231-45797934 (+)
A/J MGP_AJ_G0018173
 protein coding gene Chr11:43973720-44008177 (+)
AKR/J MGP_AKRJ_G0018139
 protein coding gene Chr11:45285191-45320690 (+)
BALB/cJ MGP_BALBcJ_G0018142
 protein coding gene Chr11:44130135-44165356 (+)
C3H/HeJ MGP_C3HHeJ_G0017956
 protein coding gene Chr11:45312856-45351129 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018596
 protein coding gene Chr11:47123007-47161020 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016251
 protein coding gene Chr11:41886438-41919081 (+)
CAST/EiJ MGP_CASTEiJ_G0017519
 protein coding gene Chr11:45452507-45489915 (+)
CBA/J MGP_CBAJ_G0017928
 protein coding gene Chr11:49309772-49350718 (+)
DBA/2J MGP_DBA2J_G0018038
 protein coding gene Chr11:43755297-43789088 (+)
FVB/NJ MGP_FVBNJ_G0018032
 protein coding gene Chr11:43408999-43443090 (+)
LP/J MGP_LPJ_G0018110
 protein coding gene Chr11:46007238-46045333 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018056
 protein coding gene Chr11:50833526-50870356 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018635
 protein coding gene Chr11:45412400-45450107 (+)
PWK/PhJ MGP_PWKPhJ_G0017299
 protein coding gene Chr11:43856501-43891596 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017092
 protein coding gene Chr11:45239963-45276930 (+)
WSB/EiJ MGP_WSBEiJ_G0017569
 protein coding gene Chr11:45108816-45141997 (+)



Homology
more
  • Human Ortholog
    TIMD4, T cell immunoglobulin and mucin domain containing 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TIMD4, T cell immunoglobulin and mucin domain containing 4
  • Synonyms
    SMUCKLER, TIM4
  • Links
    NCBI Gene ID: 91937
    neXtProt AC: NX_Q96H15
    UniProt: Q96H15

  • Chr Location
    5q33.3; chr5:156919292-156963226 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Timd4 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 3 alleles in 3 genetic backgrounds
    3 phenotypes from multigenic genotypes
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired macrophage phagocytosis, altered macrophage physiology, and increased peritoneal lymphoid and meyloid cell numbers.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    715
  • Tissues
    9
  • cDNA Data
    12
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000055546 Ensembl Gene Model | MGI Sequence Detail 33533 C57BL/6J ±  kb
    transcript ENSMUST00000068877 Ensembl | MGI Sequence Detail 2173 Not Applicable  
    polypeptide ENSMUSP00000069456 Ensembl | MGI Sequence Detail 343 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 12
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 5
      Phenotypes 34
    • Earliest
      J:13080 DICKIES MM, A new viable yellow mutation in the house mouse. J Hered. 1962 Mar-Apr;53:84-6
    • Latest
      J:340077 Ding L, et al., T-cell immunoglobulin- and mucin-domain-containing molecule-4 maintains adipose tissue homeostasis by orchestrating M2 macrophage polarization via nuclear factor kappa B pathway. Immunology. 2023 Jan;168(1):49-62
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory