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Hs3st5 Gene Detail
Summary
  • Symbol
    Hs3st5
  • Name
    heparan sulfate (glucosamine) 3-O-sulfotransferase 5
  • Synonyms
    D930005L05Rik, LOC382362
  • Feature Type
    protein coding gene
  • IDs
    MGI:2441996
    NCBI Gene: 319415
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:36382810-36710393 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 19.31 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    16387 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2441996
 protein coding gene Chr10:36382794-36710393 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017143
 protein coding gene Chr10:34915282-35259288 (+)
A/J MGP_AJ_G0017120
 protein coding gene Chr10:34004403-34338540 (+)
AKR/J MGP_AKRJ_G0017080
 protein coding gene Chr10:34419857-34776805 (+)
BALB/cJ MGP_BALBcJ_G0017083
 protein coding gene Chr10:33971665-34295083 (+)
C3H/HeJ MGP_C3HHeJ_G0016903
 protein coding gene Chr10:34736417-35080375 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017541
 protein coding gene Chr10:35971938-36313717 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015238
 protein coding gene Chr10:32156242-32448075 (+)
CAST/EiJ MGP_CASTEiJ_G0016482
 protein coding gene Chr10:34921674-35268298 (+)
CBA/J MGP_CBAJ_G0016877
 protein coding gene Chr10:37682936-38022238 (+)
DBA/2J MGP_DBA2J_G0016982
 protein coding gene Chr10:33570642-33895754 (+)
FVB/NJ MGP_FVBNJ_G0016977
 protein coding gene Chr10:33066570-33390087 (+)
LP/J MGP_LPJ_G0017059
 protein coding gene Chr10:34898509-35232713 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017007
 protein coding gene Chr10:38399156-38784206 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017577
 protein coding gene Chr10:34402598-34733378 (+)
PWK/PhJ MGP_PWKPhJ_G0016263
 protein coding gene Chr10:33358970-33678674 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016047
 protein coding gene Chr10:34255246-34577871 (+)
WSB/EiJ MGP_WSBEiJ_G0016545
 protein coding gene Chr10:34683968-35026856 (+)



Homology
more
  • Human Ortholog
    HS3ST5, heparan sulfate-glucosamine 3-sulfotransferase 5
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HS3ST5, heparan sulfate-glucosamine 3-sulfotransferase 5
  • Synonyms
    3-OST-5, 3OST5, HS3OST5, NBLA04021
  • Links
    NCBI Gene ID: 222537
    UniProt: Q8IZT8

  • Chr Location
    6q21-q22.1; chr6:114055596-114343023 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    4
  • cDNA Data
    8
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000044499 Ensembl Gene Model | MGI Sequence Detail 327584 C57BL/6J ±  kb
    transcript ENSMUST00000058738 Ensembl | MGI Sequence Detail 3078 Not Applicable  
    polypeptide ENSMUSP00000060229 Ensembl | MGI Sequence Detail 346 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 8
      Primer pair 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2685997
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 13
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:353621 Patel VN, et al., Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation. Nat Commun. 2024 Aug 31;15(1):7584
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory