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Atf5 Gene Detail
Summary
  • Symbol
    Atf5
  • Name
    activating transcription factor 5
  • Synonyms
    AFTA, Atf7, Atfx, ODA-10
  • Feature Type
    protein coding gene
  • IDs
    MGI:2141857
    NCBI Gene: 107503
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:44461680-44466082 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 28.92 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    168 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2141857
 protein coding gene Chr7:44461680-44466082 (-)
129S1/SvImJ ENSMUSG00200027686
 protein coding gene Chr7:32057465-32061851 (-)
A/J ENSMUSG00195037203
 protein coding gene Chr7:36085532-36089918 (-)
AKR/J ENSMUSG00220007279
 protein coding gene Chr7:30390374-30394776 (-)
BALB/cJ ENSMUSG00180036096
 protein coding gene Chr7:32960925-32965311 (-)
C3H/HeJ ENSMUSG00175030842
 protein coding gene Chr7:33493395-33497781 (-)
C57BL/6NJ ENSMUSG00215043641
 protein coding gene Chr7:32754432-32758834 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029675
 protein coding gene Chr7:46746488-46750777 (-)
CAST/EiJ ENSTCUG00005046884
 protein coding gene Chr7:36470547-36474956 (-)
CBA/J ENSMUSG00210048120
 protein coding gene Chr7:33864760-33869146 (-)
DBA/2J ENSMUSG00185045083
 protein coding gene Chr7:37737391-37741777 (-)
FVB/NJ ENSMUSG00205044719
 protein coding gene Chr7:33409970-33414372 (-)
JF1/MsJ ENSUMUG00000016940
 protein coding gene Chr7:42225767-42230189 (-)
LP/J ENSMUSG00230051458
 protein coding gene Chr7:43166841-43171239 (-)
NOD/ShiLtJ ENSMUSG00190027158
 protein coding gene Chr7:33737730-33742134 (-)
NZO/HlLtJ ENSMUSG00225014095
 protein coding gene Chr7:41375427-41379825 (-)
PWK/PhJ ENSLUMG00010038782
 protein coding gene Chr7:32694255-32698673 (-)
SPRET/EiJ ENSMSPG00010040789
 protein coding gene Chr7:32470408-32474814 (-)
WSB/EiJ ENSIUOG00005022637
 protein coding gene Chr7:34281363-34285749 (-)



Homology
more
  • Human Ortholog
    ATF5, activating transcription factor 5
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ATF5, activating transcription factor 5
  • Synonyms
    ATFX, HMFN0395
  • Links
    NCBI Gene ID: 22809
    UniProt: Q9Y2D1

  • Chr Location
    19q13.33; chr19:49923910-49933935 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    1 images
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit partial neonatal and postnatal lethality, absence of gastric milk in some mice, decreased body weight in mice that survive and loss of mature olfactory sensory neurons with increased apoptosis in olfactory epithelium.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    86
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1004
  • Tissues
    219
  • cDNA Data
    141
  • Literature Summary
    27
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 107503 NCBI Gene Model | MGI Sequence Detail 4403 C57BL/6J ±  kb
    transcript NR_033136 RefSeq | MGI Sequence Detail 1833 C57BL/6  
    polypeptide O70191 UniProt | EBI | MGI Sequence Detail 283 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 149
      cDNA 142
      Primer pair 6
      Other 1
      Antibodies 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1446, MGI:1858966, MGI:88097
    References
    more
    • Summaries
      All 90
      Developmental Gene Expression 27
      Gene Ontology 15
      Phenotypes 23
    • Earliest
      J:2973 Nishizawa M, et al., cDNA clones encoding leucine-zipper proteins which interact with G-CSF gene promoter element 1-binding protein. FEBS Lett. 1992 Mar 24;299(1):36-8
    • Latest
      J:391329 Duan CH, et al., Loss of Echs1 in neural stem and progenitor cells impairs neurogenesis via ER stress activation and lipid metabolic reprogramming. Nat Commun. 2026 Jul 1;17(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory