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Kcp Gene Detail
Summary
  • Symbol
    Kcp
  • Name
    kielin/chordin-like protein
  • Synonyms
    Crim2, KCP, LOC333088
  • Feature Type
    protein coding gene
  • IDs
    MGI:2141640
    NCBI Gene: 333088
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:29473161-29507951 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 12.36 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    78 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2141640
 protein coding gene Chr6:29473161-29508006 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030526
 protein coding gene Chr6:27270662-27307079 (-)
A/J MGP_AJ_G0030499
 protein coding gene Chr6:26113438-26149427 (-)
AKR/J MGP_AKRJ_G0030426
 protein coding gene Chr6:26977237-27011792 (-)
BALB/cJ MGP_BALBcJ_G0030509
 protein coding gene Chr6:26271174-26305906 (-)
C3H/HeJ MGP_C3HHeJ_G0030222
 protein coding gene Chr6:26974763-27009840 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030963
 protein coding gene Chr6:28051962-28086799 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028174
 protein coding gene Chr6:24321848-24357496 (-)
CAST/EiJ MGP_CASTEiJ_G0029624
 protein coding gene Chr6:26776782-26815225 (-)
CBA/J MGP_CBAJ_G0030200
 protein coding gene Chr6:29111877-29148740 (-)
DBA/2J MGP_DBA2J_G0030344
 protein coding gene Chr6:26062321-26097308 (-)
FVB/NJ MGP_FVBNJ_G0030298
 protein coding gene Chr6:25816294-25851238 (-)
LP/J MGP_LPJ_G0030431
 protein coding gene Chr6:27402208-27439701 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030334
 protein coding gene Chr6:31613868-31652774 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030993
 protein coding gene Chr6:26851070-26887287 (-)
PWK/PhJ MGP_PWKPhJ_G0029338
 protein coding gene Chr6:25594827-25629827 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029174
 protein coding gene Chr6:26569786-26605633 (-)
WSB/EiJ MGP_WSBEiJ_G0029700
 protein coding gene Chr6:26821632-26857763 (-)



Homology
more
  • Human Ortholog
    KCP, kielin cysteine rich BMP regulator
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCP, kielin cysteine rich BMP regulator
  • Synonyms
    CRIM2, KCP1, NET67
  • Links
    NCBI Gene ID: 375616
    neXtProt AC: NX_Q6ZWJ8
    UniProt: Q6ZWJ8

  • Chr Location
    7q32.1; chr7:128862042-128910719 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display increased sensitivity to renal injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    23
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000059022 Ensembl Gene Model | MGI Sequence Detail 34791 C57BL/6J ±  kb
    transcript ENSMUST00000101614 Ensembl | MGI Sequence Detail 4885 Not Applicable  
    polypeptide ENSMUSP00000099135 Ensembl | MGI Sequence Detail 1550 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      Genomic 1
      cDNA 23

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2685639
    References
    more
    • Summaries
      All 28
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 6
    • Earliest
      J:97529 Lin J, et al., Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease. Nat Med. 2005 Apr;11(4):387-93
    • Latest
      J:296151 Liu J, et al., Transcriptional analysis of cleft palate in TGFbeta3 mutant mice. Sci Rep. 2020 Sep 10;10(1):14940
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory