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Lias
Gene Detail
Symbol

Name
ID
Lias
lipoic acid synthetase
MGI:1934604
Synonyms
2900022L22Rik, 4933425M12Rik, 7a5ex, MGC7254, mLip1
Feature Type
protein coding gene
Genetic Map
Chromosome 5
33.66 cM, cytoband C3.3
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr5:65391497-65410693 bp, + strand
From VEGA annotation of GRCm38

  19197 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4997  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog; 1 zebrafish

Protein SuperFamily: lipoyl synthase
Gene Tree: Lias

Human
homologs
Human Homolog LIAS, lipoic acid synthetase
NCBI Gene ID 11019
neXtProt AC  NX_O43766
Human Synonyms  LAS, LIP1, LS, PDHLD
Human Chr (Location)  4p14; chr4:39458989-39477653 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human LIAS
Mutations,
alleles, and
phenotypes
All mutations/alleles(21) : Chemically induced (ENU)(1) Gene trapped(17) Targeted(3)
Incidental mutations (data from APF )
 
Mice homozygous for a gene trap allele die before weaning. Embryos homozygous for a null allele become growth arrested and die at E7.5-E9.5. Embryos homozygous for an ENU allele survive to E12.5 showing a growth delay, an open neural tube, microcephaly, dilated hearts and lack of dorsal forebrain.
 
Interactions
Lias interacts with 199 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process inflammatory response, lipoate biosynthetic process, ...
Component mitochondrion
Function 4 iron, 4 sulfur cluster binding, catalytic activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (94)    Tissues (94)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(63)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(66) cDNA(66)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000028341 (Evidence)
Ensembl Gene ModelENSMUSG00000029199 (Evidence)
Entrez Gene79464 (Evidence)
UniGene195776
DFCITC1576426, TC1603455
DoTSDT.101734615, DT.94381873
NIA Mouse Gene IndexU005627
EC2.8.1.8
Consensus CDS ProjectCCDS19307.1
International Mouse Knockout Project StatusLias
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028341 VEGA Gene Model | MGI Sequence Detail 19197 C57BL/6J ±  kb
transcript OTTMUST00000070247 VEGA | MGI Sequence Detail 3154 Not Applicable 
polypeptide OTTMUSP00000035767 VEGA | MGI Sequence Detail 373 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(6) UniProt(3)
Polymorphisms
SNPs within 2kb(143 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013785 Aldolase-type TIM barrel
InterPro IPR006638 Elongator protein 3/MiaB/NifB
InterPro IPR003698 Lipoyl synthase
InterPro IPR007197 Radical SAM
Protein Ontology PR:000009798 lipoyl synthase, mitochondrial
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(44)
Other
accession IDs
MGI:1918344, MGI:1924081, MGI:2141287, MGI:3578164

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory