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Lias Gene Detail
Summary
  • Symbol
    Lias
  • Name
    lipoic acid synthetase
  • Synonyms
    2900022L22Rik, 4933425M12Rik, 7a5ex, MGC7254, mLip1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1934604
    NCBI Gene: 79464
Location & Maps
more
  • Sequence Map
    Chr5:65391540-65410693 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      19154 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 33.66 cM, cytoband C3.3
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    LIAS, lipoic acid synthetase
  • Vertebrate Orthologs
    11
  • Human Ortholog
    LIAS, lipoic acid synthetase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HGCLAS, HUSSY-01, LAS, LIP1, LS, PDHLD
  • Links
    NCBI Gene ID: 11019
    neXtProt AC: NX_O43766

  • Chr Location
    4p14; chr4:39459024-39477653 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human LIAS associations

Human Disease Mouse Models
       Hyperglycinemia, Lactic Acidosis, and Seizures; HGCLAS   OMIM: 614462
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 3 alleles in 5 genetic backgrounds
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    25
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Gene trapped
    17
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    4 involving Lias
  • Incidental Mutations
    APF
Mice homozygous for a gene trap allele die before weaning. Embryos homozygous for a null allele become growth arrested and die at E7.5-E9.5. Embryos homozygous for an ENU allele survive to E12.5 showing a growth delay, an open neural tube, microcephaly, dilated hearts and lack of dorsal forebrain.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028341 VEGA Gene Model | MGI Sequence Detail 19154 C57BL/6J ±  kb
transcript OTTMUST00000070249 VEGA | MGI Sequence Detail 2996 Not Applicable  
polypeptide OTTMUSP00000035768 VEGA | MGI Sequence Detail 289 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    143 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 66
    cDNA 66

    Microarray probesets 5
Other
Accession IDs
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MGI:1918344, MGI:1924081, MGI:2141287, MGI:3578164
References
more
  • Summaries
    All 40
    Developmental Gene Expression 2
    Gene Ontology 8
    Phenotypes 27
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory